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850366P

Avanti

18:0 (9,10dibromo) PC

1,2-di-(9,10-dibromo)stearoyl-sn-glycero-3-phosphocholine, powder

Synonym(s):

1,2-di-(9,10-dibromooctadecanoyl)-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C44H84NO8PBr4
CAS Number:
217075-01-9
Molecular Weight:
1105.73
UNSPSC Code:
51191904
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (850366P-10mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850366P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC(Br)C(Br)CCCCCCCC)=O)COC(CCCCCCCC(Br)C(Br)CCCCCCCC)=O)=O

General description

18:0 (9,10dibromo) PC (1,2-di-(9,10-dibromo)stearoyl-sn-glycero-3-phosphocholine) is a zwitterionic[1] and brominated phospholipid.[2]

Application

18:0 (9,10dibromo) PC (1,2-di-(9,10-dibromo)stearoyl-sn-glycero-3-phosphocholine) may be used:
  • in the preparation of liposomes/small unilamellar vesicles (SUVs)[2]
  • in the preparation of large unilamellar vesicles (LUVs) to facilitate vesicles sedimentation[1]
  • as a component in liposomes[3]

Biochem/physiol Actions

Phosphatidylcholine (PC) serves as a surfactant to prevent the penetrance of bacteria.[4] Brominated lipids are capable of recognizing the lipid binding sites on the surface of the reaction center from Rhodobacter sphaeroides.[5]

Packaging

5 mL Clear Glass Sealed Ampule (850366P-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Inflammatory Bowel Disease
Integrative Medicine, 501-516 (2018)
Aleksander W Roszak et al.
Biochemistry, 46(11), 2909-2916 (2007-02-24)
This study describes the use of brominated phospholipids to distinguish between lipid and detergent binding sites on the surface of a typical alpha-helical membrane protein. Reaction centers isolated from Rhodobacter sphaeroides were cocrystallized with added brominated phospholipids. X-ray structural analysis
Jocelyn Méré et al.
The Biochemical journal, 386(Pt 1), 47-56 (2004-11-06)
Gelsolin is a calcium-, pH- and lipid-dependent actin filament severing/capping protein whose main function is to regulate the assembly state of the actin cytoskeleton. Gelsolin is associated with membranes in cells, and it is generally assumed that this interaction is
Maria Jesús Sánchez-Martín et al.
Journal of colloid and interface science, 360(1), 124-131 (2011-05-14)
The aim of this study was to identify proteins that could inhibit the activity of the peptide sequence representing the N-terminal of the surface protein gp41 of HIV, corresponding to the fusion peptide of the virus (HIV-1 FP). To do
Olatz Landeta et al.
The Journal of biological chemistry, 286(10), 8213-8230 (2011-01-05)
BAK is a key effector of mitochondrial outer membrane permeabilization (MOMP) whose molecular mechanism of action remains to be fully dissected in intact cells, mainly due to the inherent complexity of the intracellular apoptotic machinery. Here we show that the

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