850347C

14:1 (Δ9-Trans) PC

1,2-dimyristelaidoyl-sn-glycero-3-phosphocholine, chloroform

• Synonym(s): 1,2-di-(9E-tetradecenoyl)-sn-glycero-3-phosphocholine; PC(14:1(9E)/14:1(9E))
• Empirical Formula (Hill Notation): C₃₆H₆₈NO₈P
• CAS Number: 76733-52-3
• Molecular Weight: 673.90
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• assay: >99% (TLC)
• form: liquid
• packaging: pkg of 1 × 2.5 mL (850347C-25mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 850347C
• concentration: 10 mg/mL (850347C-25mg)
• lipid type: phospholipids; cardiolipins
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

Phosphatidylcholine represents 58% of phospholipids in the mammalian membranes. It is accumulated in axon.[1] It is the first amphiphiles to be discovered.[2]

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

14:1 (Δ9-Trans) PC (1,2-dimyristelaidoyl-sn-glycero-3-phosphocholine) has been used as an internal standard during lipid extraction from various samples for high performance liquid chromatography (HPLC),[3] 2D liquid chromatography-mass spectrometry (LC-MS)[4][5] and spectrophotometric analysis.[6] It has also been used in the preparation of bicelles and mixed with amphiphiles for nuclear magnetic resonance (NMR) studies.[7]

Biochem/physiol Actions

Phosphatidylcholine (PC) is the key component in the eukaryotic cell membranes.[8] PC is a major component in rat peritoneal surface. It aids in peritoneal solute transport and water ultrafiltration in rat.[6] The signaling pathway of PC is implicated in bile metabolism and glucose homeostasis.[2] PC functions as a neurotrophin like factor and regulates neuronal plasticity and cell fate.[1] Perturbation of PC homeostasis is known to cause many neurodegenerative disorders.[8]

Packaging

5 mL Clear Glass Sealed Ampule (850347C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302,H315,H319,H331,H336,H351,H361d,H372
• pcodes: P201 - P260 - P264 - P280 - P304 + P340 + P311 - P403 + P233
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• target_organs: Central nervous system
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: does not flash
• flash_point_c: does not flash