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840008C

Avanti

Lyso PAF (from Heart PC)

Avanti Research™ - A Croda Brand 840008C

Synonym(s):

1-alkyl-2-hydroxy-sn-glycero-3-phosphocholine

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About This Item

CAS Number:
52691-62-0
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (840008C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840008C

concentration

5 mg/mL (840008C-5mg)

lipid type

phospholipids
phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C24H52NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-29-22-24(26)23-31-32(27,28)30-21-19-25(2,3)4/h24,26H,5-23H2,1-4H3/t24-/m1/s1

InChI key

VLBPIWYTPAXCFJ-XMMPIXPASA-N

General description

Lyso-platelet activating factor (lyso-PAF) is the alkyl homolog of lysophosphatidylcholine.[1]

Application

Lyso PAF (from Heart PC) is suitable for use as acyl acceptors in the determination of lysophosphatidic acid acyltransferase (LPAAT) activity.[2] It is also suitable for use in mass spectroscopic comparison for identifying the presence of tiny amounts of alkylacylphosphatidylcholine (OxPAF) in oxidized low density lipoprotein (OxLDL).[3]

Biochem/physiol Actions

Lyso-platelet activating factor (lyso-PAF) can stimulate inflammation in a murine model of pleurisy.[1] It acts as a stable metabolite and a precursor of PAF. The turnover of lyso-PAF to PAF is expected to induce continued inflammation in target organs or tissues.[4]

Packaging

5 mL Clear Glass Sealed Ampule (840008C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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Study on the metabolism of lyso-platelet activating factor (lyso-PAF) in human paranasal sinus mucosa. The cultured ciliated epithelium can convert lyso-PAF to PAF
Inoue H, et al.
Life Sciences, 52(21), PL227-PL232 (1993)
Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids
Chen X, et al.
Journal of Lipid Research, 49(4), 832-846 (2008)
Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids
Marathe GK, et al.
Journal of Lipid Research, 42(9), 1430-1437 (2001)
C Eberhardt et al.
The Journal of biological chemistry, 272(32), 20299-20305 (1997-08-08)
Lysophosphatidic acid (1-acyl-sn-glycero-3-phosphate (LPA)) is a phospholipid with diverse biological activities. The mediator serves as an intermediate in membrane phospholipid metabolism but is also produced in acute settings by activated platelets. LPA is converted to phosphatidic acid, itself a lipid

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