830865P

18:0 PA

Avanti Research^™ - A Croda Brand

• Synonym(s): 1,2-dioctadecanoyl-sn-glycero-3-phosphate (sodium salt); DSPA; PA(18:0/18:0)
• Empirical Formula (Hill Notation): C₃₉H₇₆O₈PNa
• CAS Number: 108321-18-2
• Molecular Weight: 726.98
• MDL number: MFCD00153888
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• description: 1,2-distearoyl-sn-glycero-3-phosphate (sodium salt)
• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 25 mg (830865P-25mg); pkg of 1 × 500 mg (830865P-500mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: cardiolipins; phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [Na+].[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC)O
• InChI: 1S/C39H77O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h37H,3-36H2,1-2H3,(H2,42,43,44);/q;+1/p-1/t37-;/m1./s1
• InChI key: ALPWRKFXEOAUDR-GKEJWYBXSA-M

Description

General description

Phosphatidic acid (PA) has two fatty acids and one phosphate group attached to a glycerol backbone. The two fatty acids are present at position sn-1 and sn-2 of the C-atoms and the phosphate group is present in the sn-3 position of the C-atom.[1]

Application

18:0 PA may be used:

• as a component in the bilayer to study its vesiculation ability on different coat protein I (COPI) fission factor[2]
• to study its effects on intracellular Ca²⁺ concentration ([Ca^2+]i) in C6 rat glioma and L2071 mouse fibroblast cells[3]
• to study its effects on phosphorylation of cytochrome b(558) alpha chain (p22phox)[4]

Biochem/physiol Actions

Phosphatidic acid (PA) acts as a biosynthetic precursor for the production of membrane glycerophospholipid and triacylglycerol. It participates in the modulation of mammalian target of rapamycin (mTOR) pathway.[1] It may also participate in membrane trafficking, specifically in membrane fusion and fission.[5]

Packaging

20 mL Clear Glass Screw Cap Vial (830865P-500mg)

5 mL Amber Glass Screw Cap Vial (830865P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable