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830841C

Avanti

06:0 PA

1,2-dihexanoyl-sn-glycero-3-phosphate (sodium salt), chloroform

Synonym(s):

1,2-dicaproyl-sn-glycero-3-phosphate (sodium salt); PA(6:0/6:0)

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About This Item

Empirical Formula (Hill Notation):
C15H28O8PNa
CAS Number:
321883-53-8
Molecular Weight:
390.34
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (830841C-10mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 830841C

concentration

10 mg/mL (830841C-10mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O)=O)(OC(CCCCC)=O)COC(CCCCC)=O.[Na+]

InChI

1S/C15H29O8P.Na/c1-3-5-7-9-14(16)21-11-13(12-22-24(18,19)20)23-15(17)10-8-6-4-2;/h13H,3-12H2,1-2H3,(H2,18,19,20);/q;+1/p-1/t13-;/m1./s1

InChI key

RSKVQVAHZSAALH-BTQNPOSSSA-M

General description

Phosphatidic acid synthesis from phosphatidylcholine is mediated by phospholipase D.[1]

Application

06:0 PA may be used in liposome flotation assay to study its interactions between purified dynamin-related protein 1 (Drp1).[2] It may also be used to study its effect in coat protein I (COPI) vesicle fission and transport.[3] It has been used in the preparation of the ubiquitin specific peptidase 1- mitochondrial distribution and morphology protein 35 (Ups1–Mdm35)– phosphatidic acid (PA) complex for crystallization studies.[4]

Biochem/physiol Actions

Phosphatidic acid might serve as a modulator of phagocyte respiratory burst. It also acts as a precursor of diacylglycerol and lysophosphatidic acid.[1]

Packaging

5 mL Clear Glass Sealed Ampule (830841C-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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Glycerolipids in signal transduction
New comprehensive biochemistry, 31, 237-255 (1996)
Yoshihiro Adachi et al.
Bio-protocol, 7(9) (2017-08-25)
A mitochondrion is a dynamic intracellular organelle that actively divides and fuses to control its size, number and shape in cells. A regulated balance between mitochondrial division and fusion is fundamental to the function, distribution and turnover of mitochondria (Roy
Seung-Yeol Park et al.
Nature communications, 10(1), 3409-3409 (2019-08-01)
Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage
Yasunori Watanabe et al.
Nature communications, 6, 7922-7922 (2015-08-04)
Eukaryotic cells are compartmentalized into membrane-bounded organelles whose functions rely on lipid trafficking to achieve membrane-specific compositions of lipids. Here we focused on the Ups1-Mdm35 system, which mediates phosphatidic acid (PA) transfer between the outer and inner mitochondrial membranes, and

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