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810331C

Avanti

18:1 Pyrene PE

Avanti Research™ - A Croda Brand 810331C

Synonym(s):

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(1-pyrenesulfonyl) (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C57H89N2O10PS
CAS Number:
384832-93-3
Molecular Weight:
1025.36
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810331C-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810331C

concentration

1 mg/mL (810331C-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

Pyrene is made up of four fused benzol rings. It is an apolar molecule.[1] Phosphatidylethanolamine (PE), a phospholipid is found abundantly in mammalian cells. In mammalian cells, 15-25% of the total lipid consists of PE. The inner mitochondrial membrane has PE in abundance.[2]

Application

18:1 Pyrene PE has been used:
  • as a quencher of protein intrinsic emission tryptophan in quenching assays of membrane proximity[3]
  • to incorporate in vesicle membranes for fluorescence spectroscopy studies[4]
  • to label vesicles to confirm the presence of hybrid vesicles in flow-cytometric analysis[5]

Biochem/physiol Actions

Phosphatidylethanolamine (PE) can serve as a lipid chaperone that supports in the folding of membrane proteins. It plays a key role in the activity of respiratory complexes. PE also participates in the initiation of autophagy.[2]

Packaging

5 mL Amber Glass Screw Cap Vial (810331C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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Certificates of Analysis (COA)

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Ethanolamine and phosphatidylethanolamine: partners in health and disease
Patel D and Witt SN
Oxidative Medicine and Cellular Longevity (2017)
Membrane Fluidity Is a Key Modulator of Membrane Binding, Insertion, and Activity of 5-Lipoxygenase
Pande AH, et al.
Biophysical Journal, 88(6), 4084-4094 (2005)
beta-Carotene-Lipid Interactions in Liposomes with Different Lipid Composition
Advances in pharmacognosy and phytomedicine, 14, 293-307 (2011)
Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles
Lim SK, et al.
Polymers, 5(3), 1102-1114 (2020)
MT1-MMP Binds Membranes by Opposite Tips of Its beta Propeller to Position It for Pericellular Proteolysis
Marcink TC, et al.
Structure, 27(2), 281-292 (2019)

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