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810264P

Avanti

C11 TopFluor™ Phytosphingosine

N-[11-(dipyrrometheneboron difluoride)undecanoyl]-phytosphingosine, powder

Synonym(s):

N-[11-(TopFluor)undecanoyl]-phytosphingosine

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About This Item

Empirical Formula (Hill Notation):
C42H72N3O4F2
CAS Number:
1246355-60-1
Molecular Weight:
721.04
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 250 μg (810264P-250ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810264P

shipped in

dry ice

Storage temp.

−20°C

General description

Phytosphingosine is a glycolipid component, present in the intestine of vertebrates.[1] It belongs to the class of sphingolipids.[2] It is seen at high level in plants and fungi. Phytosphingosine is also abundantly present in the epidermis of mammals.[2]

Biochem/physiol Actions

Phytosphingosine helps to protect the skin by preventing the loss of its moisture. It plays a key role in the epidermal cell growth, differentiation and cell death. Phytosphingosine exhibits bactericidal and anti-inflammatory properties. Phytosphingosine modulates the synthesis of lipid in the epidermal stratum corneum. It is capable of blocking nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling.[2] Phytosphingosine is known to participate in the differentiation of keratinocytes.[3]

Packaging

5 mL Amber Glass Screw Cap Vial (810264P-250ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Phytosphingosine is a characteristic component of the glycolipids in the vertebrate intestine.
Nishimura K
Comparative Biochemistry and Physiology. B, Comparative Biochemistry, 86(1), 149-154 (1987)
Analysis of skin penetration of phytosphingosine by fluorescence detection and influence of the thermotropic behaviour of DPPC liposomes
Hasanovic A, et al.
International Journal of Pharmaceutics, 383(1), 14-17 (2010)
Byung-Hak Kim et al.
The Journal of investigative dermatology, 134(4), 1023-1032 (2013-11-02)
Phytosphingosine is abundant in plants and fungi and is found in mammalian epidermis, including the stratum corneum. Phytosphingosine and its derivatives N-acetyl phytosphingosine and tetraacetyl phytosphingosine are part of the natural defense system of the body. However, these molecules exhibit

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