810262P
Avanti
C11 TopFluor™ Ceramide
N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine, powder
Synonym(s):
N-[11-(TopFluor)undecanoyl]-D-erythro-sphingosine
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About This Item
Empirical Formula (Hill Notation):
C42H70N3O3F2
CAS Number:
Molecular Weight:
703.02
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 250 μg (810262P-250ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810262P
shipped in
dry ice
storage temp.
−20°C
General description
Ceramide, a bioactive sphingolipid belongs to the sphingolipid family of cell lipids. This pore-forming member is insoluble in water.[1] It is a hygroscopic and light sensitive lipid.
Application
C11 TopFluor™ Ceramide may be used:
- in the ceramide and B-cell lymphoma-extra-large (Bcl-xL) binding studies to study the effect on ceramide channel formation[1]
- as a tracer in confocal microscopy to treat T84 cells in order to study its localization in sphingomyelinase (SMase)-induced F-actin structures [2]
- to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy[3]
Biochem/physiol Actions
Ceramide is known to participate in apoptosis, mediated by mitochondria. Ceramide channels plays a key role in the onset of apoptosis in vivo.[1]
Packaging
5 mL Amber Glass Screw Cap Vial (810262P-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
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Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion
Saslowsky DE, et al.
Molecular Biology of the Cell, 27(7), 1120-1130 (2016)
Ceramide Channels: Destabilization by Bcl-xL and Role in Apoptosis
Chang KT, et al.
Biochimica et Biophysica Acta, 1848(10 0 0), 2374-2374 (2015)
Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide-1-phosphate promote pancreatic cancer stem cell motility
Kuc N, et al.
Biochemical Pharmacology, 156, 458-466 (2018)
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