Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

810226C

Avanti

C6-NBD Lactosyl Ceramide

Avanti Research™ - A Croda Brand 810226C

Synonym(s):

N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-lactosyl-β1-1′-sphingosine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C42H69N5O16
CAS Number:
474943-04-9
Molecular Weight:
900.02
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810226C-250ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810226C

concentration

0.25 mg/mL (810226C-250ug)

shipped in

dry ice

storage temp.

−20°C

General description

C6-NBD Lactosyl ceramide is a fluorescent derivative of biologically active compound lactosyl ceramide. Lactosyl ceramide is a glycosphingolipid that is present on neutrophils and macrophages.

application

C6-NBD Lactosyl ceramide may be used for phospholipid labeling and fluorescence-lifetime imaging microscopy (FILM) with respect to cell membranes.

Biochem/physiol Actions

Lactosyl ceramide is a precursor of various glycosphingolipids like oligoglycosylceramides and gangliosides involved in various vital cellular processes. It plays a major role in signaling cascades leading to phenotypic changes such as adhesion, migration, cell proliferation and angiogenesis. Lactosyl ceramide is a crucial molecule involved in osteoclastogenesis mediated by macrophage-colony stimulating factor.

Packaging

5 mL Amber Glass Screw Cap Vial (810226C-250ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Ana Zarubica et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(6), 1775-1785 (2009-01-20)
The ABCA1 transporter orchestrates cellular lipid homeostasis by promoting the release of cholesterol to plasmatic acceptors. The molecular mechanism is, however, unknown. We report here on the biophysical analysis in living HeLa cells of the ABCA1 lipid microenvironment at the
T Iwamoto et al.
The Journal of biological chemistry, 276(49), 46031-46038 (2001-10-11)
Glycosphingolipids and their metabolites play important roles in a variety of biological processes. Several signal molecules are localized in a glycolipid-enriched microdomain on the cell surface, and their signals are regulated by the glycolipid composition. However, the function of glycolipids
S Hakomori et al.
Journal of biochemistry, 118(6), 1091-1103 (1995-12-01)
Glycosphingolipids (GSLs), cell type-specific markers which change dramatically during ontogenesis and oncogenesis, have been implicated as playing major roles in cellular interactions and control of cell proliferation in multicellular organisms. These functional roles have been partially clarified through two types
Subroto Chatterjee et al.
Biochimica et biophysica acta, 1780(3), 370-382 (2007-12-14)
Although lactosylceramide (LacCer) plays a pivotal role in the biosynthesis of nearly all the major glycosphingolipids, its function in regulating cellular function has begun to emerge only recently. Our current opinion is that several physiologically critical molecules such as modified/oxidized
F Pincet et al.
Biophysical journal, 80(3), 1354-1358 (2001-02-27)
Carbohydrate-carbohydrate interactions are rarely considered in biologically relevant situations such as cell recognition and adhesion. One Ca(2+)-mediated homotypic interaction between two Lewis(x) determinants (Le(x)) has been proposed to drive cell adhesion in murine embryogenesis. Here, we confirm the existence of
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service