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810214P

Avanti

C6-NBD Phytosphingosine

Avanti Research™ - A Croda Brand 810214P, powder

Synonym(s):

N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-phytosphingosine

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About This Item

Empirical Formula (Hill Notation):
C30H51N5O7
CAS Number:
477239-93-3
Molecular Weight:
593.76
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 50 μg (810214P-50ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810214P

shipped in

dry ice

Storage temp.

−20°C

General description

C6-NBD Phytosphingosine is a fluorescent analog of the sphingoid compound, phytosphingosine with NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) being the fluorescent group.[1][2] Phytosphingosine is specifically localised to tissues such as skin, kidney, and intestine in animals and decrease in its production may lead to disorders. Phytosphingosine (PHS) is a major a long-chain base in yeast and mammalian cells.[2][3]

Application

C6-NBD Phytosphingosine N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-phytosphingosine is suitable to study membrane fusion with the help of fForster resonance energy transfer (FRET).[4][5]

Biochem/physiol Actions

Phytosphingosine (PHS) is an important component of phytoceramides. PHS metabolism results in the production of sphingolipids and glycerophospholipids.[2][3]

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (810214P-50ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Fluorescent and Luminescent Probes for Biological Activity (1999)
Endotoxin-adsorbing macrophage-mimetic hybrid liposome for sepsis treatment
Jiang LL, et al.
Chemical Engineering Journal, 371(1), 15-25 (2019)
Hyun Kyung Choi et al.
Archives of dermatological research, 309(10), 795-803 (2017-09-25)
Phytosphingosine (PHS) is a sphingoid that is a key component of phytoceramides NP, AP and EOP. PHS has been known to have anti-inflammation and antimicrobial activities and to stimulate epidermal differentiation. In addition, it is reported that PHS treatment notably
Chunai Gong et al.
Journal of nanobiotechnology, 18(1), 92-92 (2020-06-18)
Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are covered by various membrane coatings, including membranes from specialized cells or hybrid membranes
Natsuki Kondo et al.
Nature communications, 5, 5338-5338 (2014-10-28)
The long-chain base phytosphingosine is a component of sphingolipids and exists in yeast, plants and some mammalian tissues. Phytosphingosine is unique in that it possesses an additional hydroxyl group compared with other long-chain bases. However, its metabolism is unknown. Here

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