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810193P

Avanti

16:0-12:0 NBD PS

Avanti Research™ - A Croda Brand 810193P, powder

Synonym(s):

1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphoserine (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C40H71N6O13P
CAS Number:
384833-07-2
Molecular Weight:
875.00
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810193P-1mg)
pkg of 5 × 1 mg (810193P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810193P

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidylserine (PS) is a membrane phospholipid comprising 2-10% of total phospholipids.[1] It is majorly localized on the inner leaflet of plasma membrane.[1] NBD PS contains the fluorophore, 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) labelled at the headgroup of PS.[2]

Application

16:0-12:0 NBD PS might be used in a liposome for determination of phosphatidylethanolamine (PE) production by the phosphatidylserine decarboxylase 1 (Psd1p) activity assay.[3][4]

Biochem/physiol Actions

Phosphatidylserine (PS) is involved in the signaling of the coagulation cascade for homeostasis.[5] It is involved in maintaining the nerve cell membrane and myelin sheath.[6]

Packaging

5 mL Amber Glass Screw Cap Vial (810193P-1mg)
5 mL Amber Glass Screw Cap Vial (810193P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Yasushi Tamura et al.
The Journal of biological chemistry, 287(52), 43961-43971 (2012-11-06)
Phosphatidylethanolamine (PE) plays important roles for the structure and function of mitochondria and other intracellular organelles. In yeast, the majority of PE is produced from phosphatidylserine (PS) by a mitochondrion-located PS decarboxylase, Psd1p. Because PS is synthesized in the endoplasmic
Jean E Vance et al.
Progress in lipid research, 44(4), 207-234 (2005-06-28)
Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid that is synthesized by prokaryotic and eukaryotic cells. In this review we focus on genes and enzymes that are involved in PS biosynthesis in bacteria, yeast, plants and mammalian cells and discuss
Ouma Onguka et al.
The Journal of biological chemistry, 290(20), 12744-12752 (2015-04-02)
Phosphatidylethanolamine (PE) is a major cellular phospholipid that can be made by four separate pathways, one of which resides in the mitochondrion. The mitochondrial enzyme that generates PE is phosphatidylserine decarboxylase 1 (Psd1p). The pool of PE produced by Psd1p
Soumi Mukherjee et al.
Chemistry and physics of lipids, 127(1), 91-101 (2004-01-07)
Lipids that are labeled with the NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl) group are widely used as fluorescent analogues of native lipids in biological and model membranes to monitor a variety of processes. NBD-labeled lipids have previously been used to monitor the organization and
Michael J Glade et al.
Nutrition (Burbank, Los Angeles County, Calif.), 31(6), 781-786 (2015-05-03)
The aim of this study was to assess the roles and importance of phosphatidylserine (PS), an endogenous phospholipid and dietary nutrient, in human brain biochemistry, physiology, and function. A scientific literature search was conducted on MEDLINE for relevant articles regarding
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