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810132C

Avanti

18:1-06:0 NBD PC

Avanti Research™ - A Croda Brand 810132C

Synonym(s):

1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C38H64N5O11P
CAS Number:
106974-05-4
Molecular Weight:
797.92
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810132C-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810132C

concentration

1 mg/mL (810132C-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

Phosphocholine is considered as a precursor molecule. It is formed during the breakdown of phosphatidylcholine (PC) metabolism. 18:1-06:0 NBD PC is a fluorescent lipid analog/probe.

Application

18:1-06:0 NBD PC is suitable for use:
  • as a component in preparing lipid solution for bilayer formation
  • to use as a single donor in fluorescence resonance energy transfer (FRET) based assay
  • to prepare phospholipid-coated beads

Biochem/physiol Actions

NBD‐PC can be used to probe the existence of (Rho‐labeled) protease‐activated receptor (PAR) pepducins in the outer and inner leaflets.

Packaging

5 mL Amber Glass Screw Cap Vial (810132C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

wgk_germany

WGK 3

Certificates of Analysis (COA)

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Large scale biomimetic membrane arrays
Hansen JS, et al.
Analytical and Bioanalytical Chemistry, 395(3), 719-727 (2009)
Yuta Ryoden et al.
Journal of immunology (Baltimore, Md. : 1950), 204(3), 559-568 (2019-12-22)
In response to extracellular ATP, the purinergic receptor P2X7 mediates various biological processes, including phosphatidylserine (PtdSer) exposure, phospholipid scrambling, dye uptake, ion transport, and IL-1β production. A genome-wide CRISPR screen for molecules responsible for ATP-induced PtdSer exposure identified a transmembrane
Anticoagulant and antithrombotic properties of intracellular protease-activated receptor antagonists
Wielders SJH, et al.
Journal of Thrombosis and Haemostasis, 5(3), 571-576 (2007)
Coordinated balance of Rac1 and RhoA plays key roles in determining phagocytic appetite
Kim SY, et al.
PLoS ONE, 12(4), e0174603-e0174603 (2017)
Johan Tornmalm et al.
Scientific reports, 9(1), 18133-18133 (2019-12-04)
Protein-lipid interactions in cellular membranes modulate central cellular functions, are often transient in character, but occur too intermittently to be readily observable. We introduce transient state imaging (TRAST), combining sensitive fluorescence detection of fluorophore markers with monitoring of their dark
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