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791299P

Avanti

bis(18:0 PE)-DTPA (Gd)

Avanti Research - A Croda Brand 791299P, powder

Synonym(s):

bis(1,2-distearoyl-sn-glycero-3-phosphoethanolamine)-N-N′-diethylenetriaminepentaacetic acid (gadolinium salt)

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About This Item

Empirical Formula (Hill Notation):
C96H186GdN7O24P2
CAS Number:
Molecular Weight:
2041.73
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (791299P-5mg)

manufacturer/tradename

Avanti Research - A Croda Brand 791299P

shipped in

dry ice

storage temp.

−20°C

General description

bis(1,2-distearoyl-sn-glycero-3-phosphoethanolamine)-N-N′-diethylenetriaminepentaacetic acid (gadolinium salt) or bis(18:0 PE)-DTPA (Gd) comprises four copies of stearic acid. It has DTPA in the head group of ethanolamine.[1] The DTPA is attached to gadolinium ion.

Biochem/physiol Actions

Gadolinium salt based DTPA conjugated phospholipid is useful in magnetic resonance imaging (MRI) and multimodal imaging. Apart from being an MRI contrast agent, PE-DTPA (Gd) liposome is also flexible for modification for binding different targets using copper–free click–chemistry methodology.[2]

Packaging

5 mL Amber Glass Screw Cap Vial (791299P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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Jin Young Kang et al.
Immunity, 31(6), 873-884 (2009-11-26)
Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA
Pavlína Šimečková et al.
Scientific reports, 10(1), 4780-4780 (2020-03-18)
Gadolinium (Gd)-based contrast agents are extensively used for magnetic resonance imaging (MRI). Liposomes are potential nanocarrier-based biocompatible platforms for development of new generations of MRI diagnostics. Liposomes with Gd-complexes (Gd-lip) co-encapsulated with thrombolytic agents can serve both for imaging and

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