790528P
Avanti
18:1 DGS-NTA
1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt), powder
Synonym(s):
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt); DOGS NTA
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About This Item
Empirical Formula (Hill Notation):
C53H100N5O13
CAS Number:
Molecular Weight:
1015.39
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (790528P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 790528P
shipped in
dry ice
storage temp.
−20°C
General description
1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (18:1 DGS-NTA) is amphiphile. DGS-NTA is a nitrilotriacetic acid -functionalized amphiphile devoid of nickel ion.
Application
18:1 DGS-NTA 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt) has been used:
- for generation of amphiphile monolayer
- in NTA-liposome preparation for procoagulant binding studies and to study its effect on factor FXII autoactivation
- as a liposome component for lipid bilayer preparation for surface plasmon resonance studies
Biochem/physiol Actions
1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (18:1 DGS-NTA or DOGS-NTA) cannot bind to histidine due to lack of nickel ion. It is capable of self-assembly to form a stable monolayer. DOGS-NTA ammonium salt is useful in bicelle preparation.
Packaging
5 mL Clear Glass Sealed Ampule (790528P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
Certificates of Analysis (COA)
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Journal of thrombosis and haemostasis : JTH, 10(10), 2108-2115 (2012-08-22)
Upon contact with an appropriate surface, factor XII (FXII) undergoes autoactivation or cleavage by kallikrein. Zn(2+) is known to facilitate binding of FXII and the cofactor, high molecular weight kininogen (HK), to anionic surfaces. To investigate whether transition metal ions
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Journal of the American Chemical Society, 129(15), 4834-4839 (2007-03-28)
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Hartono D, et al.
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In an in vitro system that mimics the assembly of immature human immunodeficiency virus (HIV) particles, ordered arrays of HIV-1 capsid (CA) proteins encoded by the viral gag gene have been obtained by incubation of histidine-tagged capsid proteins (His-HIVCA) beneath
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