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790473C

Avanti

06:0 PC-d35

Avanti Research™ - A Croda Brand 790473C

Synonym(s):

1,2-dihexanoyl-d22-sn-glycero-3-phosphocholine-1,1,2,2-d4-N,N,N-trimethyl-d9

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About This Item

Empirical Formula (Hill Notation):
C20H5NO8PD35
CAS Number:
474942-76-2
Molecular Weight:
488.72
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (790473C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 790473C

concentration

5 mg/mL (790473C-5mg)

shipped in

dry ice

storage temp.

−20°C

General description

1,2-dihexanoyl-sn-glycero-3-phosphocholine (06:0 PC) is a phospholipid with hydrophobic acyl chain The critical micelle concentration of 06:0 PC is containing phospholipid with a critical micelle concentration of 15 mM.[1] 06:0 PC-d35 is the deuterated form of 06:0 PC.
Deuterated fatty acids experience exchange of the deuteriums on the alpha carbon to the carbonyl, i.e., C2 position, and will therefore be a mixture of compounds that are fully deuterated and partially deuterated at that position.

Application

06:0 PC-d35 has been used in bicelle preparation for dystrophin interaction studies.[2][3][4]

Biochem/physiol Actions

Phosphocholine (PC) is derived from phosphatidylcholine (lecothin) and is a ligand for nicotinic acetylcholine receptors (nAChR).[5] It also mediates immune response.[5] 1,2-dihexanoyl-sn-glycero-3-phosphocholine (06:0 PC) forms bicelle with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and takes a disc like conformation.[6] Phosphocholine (PC) is the catabolized product of phosphatidylcholine (lecithin). PC mediates immune response and acts as a ligand for nicotinic acetylcholine receptors (nAChR).[5]

Packaging

5 mL Clear Glass Sealed Ampule (790473C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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K Richter et al.
Scientific reports, 6, 28660-28660 (2016-06-29)
We demonstrated previously that phosphocholine and phosphocholine-modified macromolecules efficiently inhibit ATP-dependent release of interleukin-1β from human and murine monocytes by a mechanism involving nicotinic acetylcholine receptors (nAChR). Interleukin-1β is a potent pro-inflammatory cytokine of innate immunity that plays pivotal roles
Raphael Dos Santos Morais et al.
Langmuir : the ACS journal of surfaces and colloids, 33(26), 6572-6580 (2017-06-06)
Obtaining structural information on integral or peripheral membrane proteins is currently arduous due to the difficulty of their solubilization, purification, and crystallization (for X-ray crystallography (XRC) application). To overcome this challenge, bicelles are known to be a versatile tool for
Raphael Dos Santos Morais et al.
Biophysical journal, 115(7), 1231-1239 (2018-09-11)
Scaffolding proteins play important roles in supporting the plasma membrane (sarcolemma) of muscle cells. Among them, dystrophin strengthens the sarcolemma through protein-lipid interactions, and its absence due to gene mutations leads to the severe Duchenne muscular dystrophy. Most of the
Systematic Characterization of DMPC/DHPC Self-Assemblies and Their Phase Behaviors in Aqueous Solution
Taguchi S, et al.
Colloids and Interfaces, 2(4), 73-73 (2018)
Johannes Björnerås et al.
Biochimica et biophysica acta, 1848(11 Pt A), 2910-2917 (2015-09-06)
Mixtures of lipids and detergents are known to form bicelles at certain parameter ranges, but many uncertainties remain concerning the details of the phase behaviour of these mixtures and the morphology of the formed lipid assemblies. Here we used nuclear
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