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700089P

Avanti

Atheronal B

Avanti Research™ - A Croda Brand

Synonym(s):

3β,5β-dihydroxy-B-norcholestane-6β-carboxaldehyde

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About This Item

Empirical Formula (Hill Notation):
C27H46O3
Molecular Weight:
418.65
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700089P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

General description

Atheronal molecules may be a  new association, in the already complex inter-relationship, between inflammation, cholesterol oxidation, the tissue macrophage, and atherosclerosis.
Atheronal-B is generated by the intramolecular aldolization of atheronal-A and this interconversion is rapid. It is present in plasma and is well detectable.[1] Atheronal A and B are also referred to as cholesterol 5,6-secosterols.[2]

Biochem/physiol Actions

Atheronal-B levels are elevated in patients with cardiovascular disease like atherosclerosis.[1] Atheronal A and B favor misfolding of α-synuclein, apolipoprotein-B100 and β-amyloid by adding an aldehyde group to the lysine side chain. In addition, atheronals also modify the cationic property of myelin basic protein (MBP) leading to structural change, which contributes directly to the pathogenesis of multiple sclerosis.[2]

Packaging

5 mL Amber Glass Screw Cap Vial (700089P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

No data available

flash_point_c

No data available

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Cindy Takeuchi et al.
Biochemistry, 45(23), 7162-7170 (2006-06-07)
The proatherogenic properties of the cholesterol 5,6-secosterols (atheronal-A and atheronal-B), recently discovered in atherosclerotic arteries, have been investigated in terms of their effects on monocyte/macrophage function. A fluorescent analogue of atheronal-B (1) (50 microM), when cultured in either aqueous buffer
Natalie K Cygan et al.
Biochemistry, 50(12), 2092-2100 (2011-02-15)
Myelin degradation in the central nervous system (CNS) is a clinical hallmark of multiple sclerosis (MS). A reduction in the net positive charge of myelin basic protein (MBP) via deimination of arginine to citrulline has been shown to correlate strongly

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