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700079P

Avanti

zymosterone

Avanti Research™ - A Croda Brand

Synonym(s):

cholesta-8(9),24-dien-3-one

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About This Item

Empirical Formula (Hill Notation):
C27H42O
CAS Number:
27192-37-6
Molecular Weight:
382.62
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700079P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[C@]1(CC2)C(CCC3=C1CC[C@@]4(C)C3CCC4[C@@H](CCC=C(C)C)C)CC2=O

InChI

1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20?,23?,24?,26+,27-/m1/s1

InChI key

AUNLIRXIJAVBNM-ZSFXRWSJSA-N

Biochem/physiol Actions

Zymosterone is metabolized to cholesterol synthesis intermediate, zymosterol in the presence of enzyme hydroxysteroid (17β) dehydrogenase 7 (HSD17B7).[1] Zymosterone conversion to zymosterol catalyzed by 3-keto sterol reductase (ERG27) is a key step in yeast ergosterol biosynthesis.[2]

Packaging

5 mL Amber Glass Screw Cap Vial (700079P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Thomas Ohnesorg et al.
Journal of molecular endocrinology, 37(1), 185-197 (2006-08-12)
In both humans and mice, 17beta-hydroxysteroid dehydrogenase type-7 (HSD17B7) was described as possessing dual enzymatic functionality. The enzyme was first shown to be able to convert estrone to estradiol in vitro. Later involvement of this enzyme in postsqualene cholesterol biosynthesis
Heli Jokela et al.
Endocrinology, 151(4), 1884-1892 (2010-02-27)
Hydroxysteroid (17beta) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynthesis) in vitro. To define the metabolic role of the

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