700056P
Avanti
lathosterol-d7
Avanti Research™ - A Croda Brand
Synonym(s):
5α-Cholest-7-en-3β-ol (25,26,26,26,27,27,27-d7)
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About This Item
Empirical Formula (Hill Notation):
C27H39D7O
CAS Number:
Molecular Weight:
393.70
UNSPSC Code:
41141804
NACRES:
NA.25
Recommended Products
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700056P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
Lathosterol is a metabolite of cholesterol present in human breast milk. Lathosterol is catabolized by lathosterol 5-desaturase to 7-dehydrocholesterol, which is a precursor of cholesterol. Lathosterol-d7 is a deuterated derivative of lathosterol.
Application
Lathosterol-d7 has been used as an internal standard in gas chromatography-mass spectrometry (GC–MS) for the breast milk sterol quantification and in liquid chromatography high resolution mass spectrometry (LC–HRMS) analysis.
Biochem/physiol Actions
Lathosterol levels are direct indicators of cholesterol levels and aid in decoding metabolism defects. Elevated levels of lathosterol is implicated in cerebrotendinous xanthomatosis (CTX) and lathosterolosis. The inactivation of enzyme lathosterol 5-desaturase (SC5D) leads to accumulation of lathosterol in lathosterolosis pathology.
Packaging
5 mL Amber Glass Screw Cap Vial (700056P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
flash_point_f
No data available
flash_point_c
No data available
Certificates of Analysis (COA)
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Patrycja A Krakowiak et al.
Human molecular genetics, 12(13), 1631-1641 (2003-06-19)
Lathosterol 5-desaturase catalyzes the conversion of lathosterol to 7-dehydrocholesterol in the next to last step of cholesterol synthesis. Inborn errors of cholesterol synthesis underlie a group of human malformation syndromes including Smith-Lemli-Opitz syndrome, desmosterolosis, CHILD syndrome, CDPX2 and lathosterolosis. We
Alan H B Wu et al.
Clinica chimica acta; international journal of clinical chemistry, 430, 43-47 (2014-01-08)
The analysis of blood for β-sitosterol and campesterol is the measures of cholesterol absorption while lathosterol is a measure of cholesterol synthesis. The biological variability of β-sitosterol, campesterol, and lathosterol was measured using liquid-chromatography tandem mass spectrometry from a cohort
Monica Gelzo et al.
Lipids in health and disease, 18(1), 235-235 (2020-01-01)
Cerebrotendinous xanthomatosis (CTX) and Lathosterolosis represent two treatable inherited disorders of cholesterol metabolism that are characterized by the accumulation of cholestanol and lathosterol, respectively. The age of the patients suspected of having these disorders is highly variable due to the
Andrea Civra et al.
The Journal of steroid biochemistry and molecular biology, 193, 105424-105424 (2019-07-16)
Oxysterols are cholesterol oxidation derivatives. Those containing an additional hydroxyl group on the side chain of the cholesterol molecule result from a physiological enzymatic synthesis and include the majority of oxysterols present in the circulation. Among these, 25-hydroxycholesterol (25OHC) and
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