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700008P

Avanti

15-ketocholestene

Avanti Research™ - A Croda Brand

Synonym(s):

3β-hydroxy-5α-cholest-8(14)-en-15-one

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About This Item

Empirical Formula (Hill Notation):
C27H44O2
CAS Number:
50673-97-7
Molecular Weight:
400.64
MDL number:
MFCD00865747
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (700008P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@@H]1C[C@H]2[C@@](C3CC[C@@]4([C@H](CC(=O)C4=C3CC2)C(CCCC(C)C)C)C)(CC1)C

InChI

1S/C27H44O2/c1-17(2)7-6-8-18(3)23-16-24(29)25-21-10-9-19-15-20(28)11-13-26(19,4)22(21)12-14-27(23,25)5/h17-20,22-23,28H,6-16H2,1-5H3/t18?,19-,20-,22?,23+,26-,27+/m0/s1

InChI key

LINVVMHRTUSXHL-NDNSGUFDSA-N

General description

15-ketocholestene is the oxidized derivative of cholesterol[1] and is associated with plasma.[2]

Application

15-ketocholestene has been used to test its binding to RAb2E9 recombinant monoclonal (RAb) antibody using enzyme-linked immunosorbent assay (ELISA).[3] It has also been used as an antigen to test its reactivity with IgG in multiple sclerosis samples.[4]

Packaging

5 mL Amber Glass Screw Cap Vial (700008P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis
Bakshi R, et al.
Neurology? neuroimmunology & neuroinflammation, 3(2), e200-e200 (2016)
Are 15-oxygenated sterols present in the human circulation?
Griffiths WJ and Wang Y
Journal of Lipid Research, 52(1), 4-5 (2011)
Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis
Quintana FJ, et al.
Proceedings of the National Academy of Sciences of the USA, 105(48), 18889-18894 (2008)
Generation and characterization of a novel recombinant antibody against 15-ketocholestane isolated by phage-display
Islam MD, et al.
International Journal of Molecular Sciences, 13(4), 4937-4948 (2012)

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