700002P

F7-Cholesterol

Avanti Research^™ - A Croda Brand

• Synonym(s): 25,26,26,26,27,27,27-heptafluorocholesterol
• Empirical Formula (Hill Notation): C₂₇H₃₉OF₇
• CAS Number: 153463-21-9
• Molecular Weight: 512.59
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 5 mg (700002P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C27H39F7O/c1-16(5-4-12-25(28,26(29,30)31)27(32,33)34)20-8-9-21-19-7-6-17-15-18(35)10-13-23(17,2)22(19)11-14-24(20,21)3/h6,16,18-22,35H,4-5,7-15H2,1-3H3/t16-,18+,19+,20-,21+,22+,23+,24-/m1/s1
• InChI key: DUAIJEYNEJQOCE-OLSVQSNTSA-N

Description

General description

F7-Cholesterol is a fluorinated derivative of cholesterol. It is a cholesterol analog. F7-Cholesterol is useful as helper lipid in conjunction with vectors for DNA transfection.

Application

F7-Cholesterol has been used:

• in the preparation of liposomes for DNA delivery studies
• to investigate its rescue functionality in hedgehog signaling in sterol-depleted cells
• in preparation of monolayers for pressure and area isotherms studies

Biochem/physiol Actions

F7-Cholesterol has potential biological applications. It has a negative dipole moment. F7-Cholesterol rescues hedgehog signaling in sterol-depleted cells. The molecular orientation and phospholipid interaction of F7-cholesterol is similar to hydrogenated cholesterol.

Packaging

5 mL Amber Glass Screw Cap Vial (700002P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class: 11 - Combustible Solids