640004P
Avanti
DMABA-d4 NHS Ester
Avanti Research™ - A Croda Brand
Synonym(s):
4-(dimethylamino)benzoic acid N-hydroxysuccinimide ester-d4
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About This Item
Empirical Formula (Hill Notation):
C13H10D4N2O4
CAS Number:
Molecular Weight:
266.29
UNSPSC Code:
12352211
NACRES:
NA.25
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description
4-(dimethylamino)-2,5-dioxo-1-pyrrolidinyl ester-benzoic-2,3,5,6-d4 acid
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (640004P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
CN(C)C1=C([2H])C([2H])=C(C(ON(C(CC2)=O)C2=O)=O)C([2H])=C1[2H]
General description
The DMABA NHS ester reagents were developed by Dr. Robert Murphy′s laboratory at the University of Colorado in order to create PE derivatives where all subclasses and potentially oxidized products could be universally detected using a common precursor ion in the positive ion mode by Mass Spectrometry.
Biochem/physiol Actions
DMABA-d4 NHS Ester is a deuterium enriched 4-(dimethylamino)benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagent. It helps in assessing distribution of phosphatidylethanolamine in RAW 264.7 cells. DMABA-d4 NHS ester is used for derivatization studies.[1] DMABA esters enable lipid quantification and profiling during biological events.[2]
Deuterium enriched 4-(dimethylamino) benzoic acid (DMABA) N-hydroxysuccinimide (NHS) ester reagents (d0, d4, d6, d10) derivatize the primary amine group of lipids, such as glycerophosphoethanolamine (PE) lipid species.[3]
Packaging
5 mL Amber Glass Screw Cap Vial (640004P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
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Low-concentration ozone reacts with plasmalogen glycerophosphoethanolamine lipids in lung surfactant
Wynalda KM and Murphy RC
Chemical Research in Toxicology, 23(1), 108-117 (2009)
Gilbert O Fruhwirth et al.
Biochimica et biophysica acta, 1772(7), 718-736 (2007-06-16)
Oxidized lipids are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. The great variety of reaction products is defined by the degree of modification, hydrophobicity, chemical reactivity, physical properties and biological activity. The biological activities of
Marko Kosicek et al.
International journal of molecular sciences, 14(1), 1310-1322 (2013-01-12)
Brain is one of the richest organs in lipid content. Phospholipids (glycerophospholipids and sphingolipids) are important building blocks of cell membranes, which provide an optimal environment for protein interactions, trafficking and function. Because of that, alterations in their cellular levels
Yukiko Ueda et al.
Nutrition research (New York, N.Y.), 28(4), 239-244 (2008-12-17)
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn disease (CD), is a disorder characterized by diffuse inflammation of the gastrointestinal tract. The immune response and inflammation are mediated by polyunsaturated fatty acids and influenced by dietary fats and
Karin A Zemski Berry et al.
European journal of mass spectrometry (Chichester, England), 16(3), 463-470 (2008-01-01)
Recently, a derivative of PE, namely the 4-(dimethylamino)benzoic acid derivative has been developed with various isotope labeled variants that provided a universal precursor ion scan for diacyl, ether and plasmalogen PE lipids that can not be accomplished otherwise. This derivative
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