330654
Avanti
GM3 ELISA (Clear)
Avanti Research™ - A Croda Brand 330654
Synonym(s):
GM3 ELISA, GM3 ELISA Snoopers™, Clear, for use in absorbance applications
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About This Item
UNSPSC Code:
12352211
NACRES:
NA.84
form
liquid
manufacturer/tradename
Avanti Research™ - A Croda Brand 330654
packaging
1 ea of 1 × (ELISA strip packaged in foil pouch)
shipped in
wet ice
storage temp.
2-8°C
General description
Avanti Lipid Snoopers™ comprise lipid spotted on solid support and are stable and aid highly sensitive semi-quantitative measurements for lipid detection. Ganglioside GM3 (monosialodihexosylganglioside) are glycosphingolipids (GSLs) which are membrane-bound comprising of a sialic acid residue and an oligosaccharide head structure. It is present in milk and in kidney cells.
ELISA Snoopers™ are 8-well strips pre-coated with a single high-quality lipid species. They can be used to investigate protein-lipid interactions, and characterize and titrate lipid binding proteins. This format provides the following advantages:
The 8-well strips are available in optically clear, white, or black surfaces for use in colormetric, luminescent and fluorescent assays, respectively. Avanti Lipid Snoopers ELISA Strips allow multiple sample conditions to be probed simultaneously in a single plate making them a perfect complement to Avanti Lipid Snoopers Nitrocellulose Strips.
- quantitative lipid-protein binding studies
- assemble a 96-well plate using only the lipids of interest for binding studies
- flexibility - use 8 to 96 wells, and 1 to 12 lipids as needed.
The 8-well strips are available in optically clear, white, or black surfaces for use in colormetric, luminescent and fluorescent assays, respectively. Avanti Lipid Snoopers ELISA Strips allow multiple sample conditions to be probed simultaneously in a single plate making them a perfect complement to Avanti Lipid Snoopers Nitrocellulose Strips.
Biochem/physiol Actions
Low levels of ganglioside GM3 is implicated in the pathogenesis of rheumatoid arthritis. It modulates immunological functions by inhibiting cytokine production. High GM3 levels are also correlated to the nephrotic syndrome and diabetic nephropathy. Avanti Lipid Snoopers™ aid in probing protein–lipid interaction by chemiluminescent detection method. Snoopers™ strips are useful in characterizing lipid-binding antibodies and decoding cell signalling pathways.
Packaging
ELISA Strip Packaged in Foil Pouch (330654-1EA)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Snoopers is a trademark of Avanti Polar Lipids, LLC
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Pricing
Storage Class
12 - Non Combustible Liquids
Certificates of Analysis (COA)
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Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis
Tsukuda Y, et al.
PLoS ONE, 7(6) (2012)
Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis
Tsukuda Y, et al.
Testing, 7(6) (2012)
The missing link-likely pathogenetic role of GM3 and other gangliosides in the development of diabetic nephropathy
Vukovic I, et al.
Kidney & Blood Pressure Research, 40(3), 306-314 (2015)
Ganglioside biochemistry
Kolter, Thomas
ISRN Biochemistry, 2012 (2012)
Avanti lipid tools: connecting lipids, technology, and cell biology
Sims KH, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1841(8), 1038-1048 (2014)
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