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330001S

Avanti

E06 mAb

E06 Mouse Monoclonal Antibody (IgM), Anti-(Oxidized Phospholipid), 1X PBS (Phosphate Buffered Saline) with 0.27 mM Na2 EDTA

Synonym(s):

E06 mAb, T15 antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

assay

>95%

form

solution

packaging

pkg of 1 × 0.1 mL (polypropylene tube with screw cap (330001S-100ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand 330001S

concentration

1 mg/mL (330001S-100ug)

shipped in

dry ice

storage temp.

−70°C

General description

The E06 antibody is a murine monoclonal IgM natural antibody that binds to oxidized phospholipid and reacts with oxidized LDL, oxidized HDL and protein covalently modified by oxidized phospholipid. Each batch is verified for activity and provided with detailed protocols for the above applications.The E06 antibody was developed by Dr. Joseph Witztum at the University of California, San Diego using apolipoprotein E knock-out mice fed a high-fat diet for seven months.

Application

E06 mAb has been used as a marker to detect oxidative injury.
The E06 antibody has been used to probe atherosclerotic plaque in mice, zebrafish, rabbits, monkeys and humans. It also binds to apoptotic cells, but not viable cells, and can be used in a variety of applications, including ELISA, immunohistochemistry and Western blot analysis, as well as for in vivo imaging with MRI techniques.

Packaging

0.5 mL Polypropylene Tube with Screw Cap (330001S-100ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Arnab Chattopadhyay et al.
Journal of lipid research, 57(5), 832-847 (2016-03-12)
Mouse chow supplemented with lysophosphatidylcholine with oleic acid at sn-1 and a hydroxyl group at sn-2 (LysoPC 18:1) increased LysoPC 18:1 in tissue of the jejunum of LDL receptor (LDLR)-null mice by 8.9 ± 1.7-fold compared with chow alone. Western
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models
Schuh C, et al.
Acta Neuropathologica, 128(2), 247-266 (2014)
W Palinski et al.
The Journal of clinical investigation, 98(3), 800-814 (1996-08-01)
Many reactive products may be formed when LDL undergoes lipid peroxidation, which in turn can react with lipids, apoproteins, and proteins, generating immunogenic neoepitopes. Autoantibodies recognizing model epitopes of oxidized low density lipoprotein, such as malondialdehydelysine, occur in plasma and
Sotirios Tsimikas et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(1), 175-181 (2006-11-04)
Oxidized phospholipids (OxPL) are pro-inflammatory. We evaluated whether changes in plasma levels of OxPL associated with apolipoprotein B-100 (apoB-100) reflect changes in OxPL content in atherosclerotic plaques during dietary-induced atherosclerosis progression and regression. OxPL content was measured in plasma and
S Hörkkö et al.
The Journal of clinical investigation, 103(1), 117-128 (1999-01-12)
We recently cloned monoclonal IgM autoantibodies which bind to epitopes of oxidized low-density lipoprotein (OxLDL) from apoE-deficient mice (EO- autoantibodies). We now demonstrate that those EO- autoantibodies that were originally selected for binding to copper-oxidized low-density lipoproteins (CuOx-LDL), also bound
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