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300105S

Avanti

Dox-NP™ (5mL vial)

Avanti Research™ - A Croda Brand 300105S

Synonym(s):

Dox-NP™, Dox-NP™ (Liposomal Encapsulated Doxorubicin)

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About This Item

UNSPSC Code:
12352202

form

solution

packaging

pkg of 1 × 5 mL (with stopper and crimp cap (300105S-1EA))

manufacturer/tradename

Avanti Research™ - A Croda Brand 300105S

shipped in

wet ice

storage temp.

2-8°C

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General description

Concentration: 2 mg/ml doxorubicin HCl at pH 6.5-6.8, in 10 mM histidine buffer, with 10% w/v sucrose.Particle size and shape: Dox-NP™ mean particle size is 80 to 90 nm, with very small poly-dispersity valuePurity: >=90% of the drug is encapsulated in the long-circulating, pegylated, liposomes.Formulation: The long-circulating, pegylated, liposomal carrier is composed of N-(carbonyl-ethoxypolyethylene glycol 2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt (MPEG-DSPE), 3.19 mg/ml; fully hydrogenated soy phosphatidylcholine (HSPC), 9.58 mg/ml; cholesterol, 3.19 mg/ml, ammonium sulfate, approximately 2 mg/ml; histidine as a buffer; hydrochloric acid or sodium hydroxide for pH control; and sucrose to maintain isotonicity. Dox-NP™ is provided as a sterile, translucent, red liposomal dispersion in single-use, 2 ml or 5 ml vials.Buffer: 10 mM histidine buffer, pH 6.5-6.8, with 10% w/v sucrose.

Application

Intravenous (i.v.) injection in flank or orthotopic animal models of cancer.

Packaging

10 mL Clear Glass Vial with Stopper and Crimp Cap (300105S-1EA)

Storage and Stability

Store undiluted at 2°-8° C. Do Not Freeze.

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
Dox-NP is a trademark of Avanti Polar Lipids, LLC

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H340,H350

Hazard Classifications

Carc. 1B - Muta. 1B

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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