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W365807

Sigma-Aldrich

1,4-Cineole

≥85%

Synonym(s):

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

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About This Item

Empirical Formula (Hill Notation):
C10H18O
CAS Number:
470-67-7
Molecular Weight:
154.25
FEMA Number:
3658
Beilstein/REAXYS Number:
104974
EC Number:
207-428-9
Council of Europe no.:
11225
MDL number:
MFCD00209502
UNSPSC Code:
12164502
PubChem Substance ID:
24901835
Flavis number:
3.007

biological source

synthetic

grade

Halal

reg. compliance

FDA 21 CFR 172.515

assay

≥85%

refractive index

n20/D 1.445 (lit.)

bp

65 °C/16 mmHg (lit.)

mp

−46 °C (lit.)

density

0.887 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

spicy; vanilla

SMILES string

CC(C)C12CCC(C)(CC1)O2

InChI

1S/C10H18O/c1-8(2)10-6-4-9(3,11-10)5-7-10/h8H,4-7H2,1-3H3/t9-,10+

InChI key

RFFOTVCVTJUTAD-AOOOYVTPSA-N

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General description

1,4-Cineole is a volatile monoterpene cyclic ether typically found in the plant essential oils. It is phytotoxic and shows potent allelopathic property.

pictograms

Flame
GHS02

signalword

Warning

hcodes

H226

Hazard Classifications

Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

116.6 °F - closed cup

flash_point_c

47 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

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Allelopathic effects of volatile cineoles on two weedy plant species.
Romagni JG, et al.
Journal of Chemical Ecology, 26(1), 303-313 (2000)
L Ji et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 22(8), 489-492 (1997-08-01)
The essential oils from the dried stems of Ephedra sinica, E. intermedia and E. equisetina were analyzed by GC-MS qualitatively and GC quantitatively. One hundred and twenty-seven constituents were identified, l-alpha-terpineol (31.64%) in E. sinica, 1,4-cineole (12.80%) in E. intermedia
Patrícia Bezerra Gomes et al.
Pharmacology, biochemistry, and behavior, 96(3), 287-293 (2010-07-31)
Recent studies have shown that some monoterpenes exert anxiolytic- and depressant-like actions, however, these effects from monoterpene 1,4-cineole are still unknown. This work aimed to study the effects of 1,4-cineole in classic animal models for depression- and anxiety-like behavior, specifically
Y Asakawa et al.
Xenobiotica; the fate of foreign compounds in biological systems, 18(10), 1129-1134 (1988-10-01)
1. The metabolism of 1,4-cineole, a monoterpene ether, was studied in the rabbit. 2. Four neutral and one acidic metabolites were isolated from the urine and shown to be 9-hydroxy-1,4-cineole, 3,8-dihydroxy-1,4-cineole, 8,9-dihydroxy-1,4-cineole, 1,4-cineole-8-en-9-ol and 1,4-cineole-9-carboxylic acid.
Abdul Ahad et al.
Current drug delivery, 8(2), 213-224 (2011-01-18)
The purpose of this study was to investigate the effectiveness and mechanism(s) of percutaneous absorption of propranolol hydrochloride (PHCL) across rat and human cadaver skin using seven novel terpenes with reference to marker terpene 1,8-cineole. In-vitro skin permeation studies were
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