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QBD10760

Sigma-Aldrich

t-Boc-N-amido-dPEG®8-acid

>95% (HPLC)

Synonym(s):

t-Boc-N-amido-PEG8-COOH, t-Boc-N-amido-PEG8-acid, t-Boc-PEG-acid, BocNH-​PEG8-​CH2CH2COOH

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100 MG
$262.00

$262.00

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100 MG
$262.00

About This Item

Empirical Formula (Hill Notation):
C24H47NO12
Molecular Weight:
541.63
MDL number:
MFCD13185254
UNSPSC Code:
12352106
NACRES:
NA.22

$262.00

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assay

>95% (HPLC)

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

N(CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O)C(=O)OC(C)(C)C

InChI

1S/C24H47NO12/c1-24(2,3)37-23(28)25-5-7-30-9-11-32-13-15-34-17-19-36-21-20-35-18-16-33-14-12-31-10-8-29-6-4-22(26)27/h4-21H2,1-3H3,(H,25,28)(H,26,27)

InChI key

XYVCCDSFTREKQJ-UHFFFAOYSA-N

Features and Benefits

t-Boc-N-amido-dPEG8-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atoms-long dPEG spacer allows the introduction of a short, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEGn-acid (n=4, 8, 12, 24, 36) product series.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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William A Day et al.
Laboratory investigation; a journal of technical methods and pathology, 97(1), 104-113 (2016-11-22)
Multiplexed analysis of multiple biomarkers in a tissue sample requires use of reporter dyes with specific spectral properties that enable discrimination of signals. Conventional chromogens with broad absorbance spectra, widely used in immunohistochemistry (IHC), offer limited utility for multiplexed detection.

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