QBD10631

Bis-MAL-Lysine-dPEG^®₄-TFP ester

• Synonym(s): Polyethylene glycol
• Empirical Formula (Hill Notation): C₃₇H₄₅F₄N₅O₁₃
• Molecular Weight: 843.77
• MDL number: MFCD28385461
• UNSPSC Code: 12352108
• PubChem Substance ID: 329823944
• NACRES: NA.22

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reagent type: cross-linking reagent; reactivity: thiol reactive
• polymer architecture: shape: linear; functionality: monofunctional
• shipped in: ambient
• Storage temp.: −20°C
• SMILES string: O=C(C(NC(CCN1C(C=CC1=O)=O)=O)CCCCNC(CCN2C(C=CC2=O)=O)=O)NCCOCCOCCOCCOCCC(OC3=C(C(F)=CC(F)=C3F)F)=O
• InChI: 1S/C37H45F4N5O13/c38-24-23-25(39)35(41)36(34(24)40)59-33(53)10-15-55-17-19-57-21-22-58-20-18-56-16-12-43-37(54)26(44-28(48)9-14-46-31(51)6-7-32(46)52)3-1-2-11-42-27(47)8-13-45-29(49)4-5-30(45)50/h4-7,23,26H,1-3,8-22H2,(H,42,47)(H,43,54)(H,44,48)
• Inchi Key: QODWSCJQLAMMBN-UHFFFAOYSA-N

Description

Features and Benefits

Bis-MAL-Lysine-dPEG^®₄-TFP ester is a unique crosslinker containing two maleimide groups, one on each amine of lysine, a 4-unit, single molecular weight dPEG^® spacer arm, and a 2,3,5,6-tetrafluorophenyl (TFP) ester. Each maleimide group reacts with a sulfhydryl group, and the TFP ester reacts with a free amine. The single molecular weight dPEG^® spacer is hydrophilic and non-immunogenic. This reagent can be used to modify or form conjugates with antibodies, antibody fragments, peptides, and small molecules.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable