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H58005

Sigma-Aldrich

4-Quinolinol

98%

Synonym(s):

4-Hydroxyquinoline

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About This Item

Empirical Formula (Hill Notation):
C9H7NO
CAS Number:
611-36-9
Molecular Weight:
145.16
Beilstein/REAXYS Number:
2900
EC Number:
210-268-2
MDL number:
MFCD00006777
UNSPSC Code:
12352100
PubChem Substance ID:
24895711
NACRES:
NA.22

assay

98%

mp

200-202 °C (lit.)

SMILES string

Oc1ccnc2ccccc12

InChI

1S/C9H7NO/c11-9-5-6-10-8-4-2-1-3-7(8)9/h1-6H,(H,10,11)

InChI key

PMZDQRJGMBOQBF-UHFFFAOYSA-N

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General description

4-Quinolinol (4-quinolone) is a quinolone compound which forms the core moiety of antibacterials such as norfloxacin, nalidixic acid, ciprofloxacin and cinoxacin.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Óscar M Bautista-Aguilera et al.
International journal of molecular sciences, 21(11) (2020-06-04)
In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (QN1-19) and 13 dihydroquinolinones (DQN1-13) designed as potential multitarget small molecules (MSM) for Alzheimer's disease therapy. Contrary to our expectations, none of them showed
Josip Podobnik et al.
Biomolecules, 10(11) (2020-11-19)
Juvenile delinquency is related to several biological factors, yet very few vulnerability biomarkers have been identified. Previous data suggest that the enzyme monoamine oxidase B (MAO-B) influences several personality traits linked to the propensity to engage in delinquent behavior. Building
Eduardo Borges de Melo
European journal of medicinal chemistry, 45(12), 5817-5826 (2010-10-23)
Two multivariate studies, a PCA-SAR and a PLS-QSAR, of 3-aryl-4-hydroxyquinolin-2(1H)-one derivatives described as type I fatty acid synthase (FAS) inhibitors, are presented in this work. The variable selection was performed with the Fisher's weight and Ordered Predictors Selection (OPS) algorithm
A Morinan et al.
Journal of pharmacological methods, 13(3), 213-223 (1985-06-01)
A fluorimetric assay for monamine oxidase that uses kynuramine as the substrate is described. This method is more economic, rapid, reproducible, and sensitive than other similar procedures. Its validity has been confirmed by the study of the subcellular distribution, the
G C Ragos et al.
Farmaco (Societa chimica italiana : 1989), 53(8-9), 611-616 (1999-03-19)
A new sensitive, rapid and accurate spectrofluorimetric method, suitable for the determination of micromolar concentrations of iron(III) in bovine liver, using 4-hydroxyquinoline (4-HQ) in an alkaline medium (KOH 2.0 x 10(-2) mol/l) as fluorescent agent, is described. The fluorescence intensity
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