CF0033

Phenylsulfanyltetrafluoroethanesulphonyl fluoride

• Linear Formula: C₈H₅F₅O₂S₂
• CAS Number: 1000294-01-8
• MDL number: MFCD31922992
• UNSPSC Code: 12352101

Properties

• form: liquid
• reaction suitability: reaction type: C-C Bond Formation

Description

Application

Phenylsulfanyltetrafluoroethanesulfonyl fluoride serves as a moderately reactive phenylsulfanyltetrafluoroethanesulfonylation reagent. A phenylsulfanyltetrafluoroethyl moiety incorporated in the substrate can be treated with tributyltin hydride and generate the corresponding fluoroalkyl radical which can add to neighbouring olefins, creating tetrafluorinated carbocycles. If the substrate lacks any olefins, it can be reduced to a tetrafluoroethyl group. Generally, fluoroalkylsulfonylation of the amine nitrogen greatly lowers the pKa value of the N-H and can be used to modulate the behaviour of the drug candidate or build additional molecular complexity around the highly acidic fluoroalkylsulfonamide nitrogen.

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Other Notes

Technology Spotlight: Fluoroalkylation: Expansion of Togni Reagents

Legal Information

Product of CF Plus Chemicals.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P280 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338 + P310
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable