Research communications in chemical pathology and pharmacology, 54(1), 125-128 (1986-10-01)
In order to develop new and potent reversible MAO-B-selective inhibitors, we examined the inhibitory effects of two substrate-analogues, 5-fluoro-alpha-methyltryptamine (5-FMT) and p-chloro-beta-methylphenethylamine (p-CMP) on rat brain MAO-A and -B activity in vitro. Studies of the inhibitory effects of both analogues
Various intraperitoneal doses of 5-fluoro-alpha-methyltryptamine (5-FMT), given to mice, dose-dependently inhibited only MAOA activity, with similar degrees of inhibition in the striatum, hypothalamus and the rest of the forebrain. The activity inhibited in these regions, completely recovered to control levels
Japanese journal of pharmacology, 46(2), 197-199 (1988-02-01)
To further clarify highly MAO-A- or -B-selective inhibitory properties of 5-fluoro-alpha-methyltryptamine (5-FMT) and p-chloro-beta-methylphenethylamine (p-CMPEA), we determined the types and K1 values of inhibition of rat brain MAO-A and -B activity in vitro. The kinetic data obtained showed that 5-FMT
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