ALD00596

N-((1S,2S)-1-(3,5-Di-tert-butylphenyl)-2-(quinolin-2-yl)butyl)acetamide

≥95%

• Synonym(s): Chiral acetyl-protected aminoethyl quinoline ligand, Et-APAQ
• Empirical Formula (Hill Notation): C₂₉H₃₈N₂O
• Molecular Weight: 430.62
• MDL number: MFCD30830353
• UNSPSC Code: 12352200
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥95%
• form: powder or crystals
• reaction suitability: reaction type: C-C Bond Formation; reagent type: catalyst; reagent type: ligand; reaction type: C-H Activation
• SMILES string: N([C@@H]([C@H](CC)c2nc3c(cc2)cccc3)c1cc(cc(c1)C(C)(C)C)C(C)(C)C)C(=O)C
• InChI: 1S/C29H38N2O/c1-9-24(26-15-14-20-12-10-11-13-25(20)31-26)27(30-19(2)32)21-16-22(28(3,4)5)18-23(17-21)29(6,7)8/h10-18,24,27H,9H2,1-8H3,(H,30,32)/t24-,27-/m1/s1
• InChI key: NZPXTQVMJQHEBG-SHQCIBLASA-N

Description

Application

This chiral acetyl-protected aminoethyl quinoline (APAQ) ligand was developed by the Yu group for ligand-enabled acceleration of Pd-catalyzed enantioselective β-methylene C–H functionalization, which is important for the generation of β-chiral centers in asymmetric synthesis.

Other Notes

Ligand-accelerated enantioselective methylene C(sp³)–H bond activation

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable