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Key Documents

ALD00002

Sigma-Aldrich

Li-Quinoline Ligand

Synonym(s):

3,4-Dihydro-2,5-dimethyl-2H-pyrano[2,3-b]quinoline

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About This Item

Empirical Formula (Hill Notation):
C14H15NO
CAS Number:
Molecular Weight:
213.28
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22

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form

solid

Quality Level

reaction suitability

reagent type: catalyst
reagent type: ligand
reaction type: C-H Activation

mp

143-147 °C

SMILES string

CC1=C2C(OC(C)CC2)=NC3=C1C=CC=C3

InChI

1S/C14H15NO/c1-9-7-8-12-10(2)11-5-3-4-6-13(11)15-14(12)16-9/h3-6,9H,7-8H2,1-2H3

InChI key

ZENOEMLZOZWVRD-UHFFFAOYSA-N

Application

Ligand can be used in the presence of Pd(TFA)2 (Aldrich 299685) to promote C-H activation of β-Aryl-α-amino acids. This product has shown to be optimal with a 2:1 ratio of Ligand:Pd Source for several examples reported by the Yu group.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Related Content

Yu program focuses on efficient C–H bond activation for drug synthesis, using simple starting materials.

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