914428
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) diacrylate
average Mn ~8,400
Synonym(s):
PEG-PPG-PEG, Pluronic F-68 diacrylate, Pluronic diacrylate
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About This Item
Linear Formula:
C3H3O[C2H4O]x[C3H6O]y[C2H4O]zC3H3O2
UNSPSC Code:
12162002
Recommended Products
form
powder
mol wt
average Mn ~8,400
color
off-white to yellow
storage temp.
−20°C
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Application
Poloxamers are nonionic, triblock copolymers containg a central hydrophobic chain of poly(propylene glycol) (PPG) and two terminal hydrophilic chains of poly(ethylene glycol) (PEG). Due to their amphiphilic structure, poloxamer solutions feature temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of poloxamers are liquid at low temperature and form a gel at higher temperature, in a reversible process. This characteristic has allowed for these materials to be used as drug carriers for most routes of administration including oral, topical, intranasal, ocular, and parenteral. Acrylate-modified derivatives are most commonly used as thermosensitive hydrogels for drug delivery and 3D bioprinting applications. After casting or printing, the material can be crosslinked to preserve the hydrogel structure.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Self-Assembly of Pluronic F127 Diacrylate in Ethylammonium Nitrate: Structure, Rheology, and Ionic Conductivity before and after Photo-Cross-Linking.
Carlos R L, wt al.
Macromolecules, 49(14), 5179-5189 (2016)
Smart hydrogels for 3D bioprinting.
Shuai W, et al.
International Journal of Bioprinting, 1(1), 3-14 (2015)
Photopolymerization of Pluronic F127 diacrylate: a colloid-templated polymerization.
Manuela D B, et al.
Soft Materials, 7, 4928-4937 (2011)
Christopher J Hansen et al.
Advanced materials (Deerfield Beach, Fla.), 25(1), 96-102 (2012-10-31)
Microvascular multinozzle arrays are designed and fabricated for high-throughput printing of functional materials. Ink-flow uniformity within these multigeneration, bifurcating microchannel arrays is characterized by computer modeling and microscopic particle image velocimetry (micro-PIV) measurements. Both single and dual multinozzle printheads are
Application of thermoreversible pluoronic F-127 gels in Pharmaceutical formulations.
Escobar-Chavez J J, et al.
J. Pharm. Pharm. Sci., 9(3), 339-358 (2006)
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