910457
Poly(2-(diisopropylamino)ethyl methacrylate)
average Mn 10,000
Synonym(s):
Hydrophilic, PDPA, pH sensitive, pH-responsive
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About This Item
Linear Formula:
(C12H23NO2)n
UNSPSC Code:
12162002
NACRES:
NA.23
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form
powder or solid
mol wt
average Mn 10,000 (by NMR)
average Mn 10,000
color
white to faint yellow
PDI
≤1.3 (by GPC)
storage temp.
2-8°C
Application
Poly(2-(diisopropylamino)ethyl methacrylate) is a pH-responsvie polymer. pH-Responsive polymers are a group of stimuli-responsive polymers that can respond to solution pH by undergoing structural and property changes such as surface activity, chain conformation, solubility, and configuration. The term “pH-responsive polymers” is commonly used to describe polymers having ionisable acidic or basic residues whose ionization depends on solution pH. The physical properties of the polymer, such as its chain conformation, configuration, and solubility, can be tailored by manipulating the pH or ionic strength. These unique properties of pH responsive polymer systems consequently make them very useful in various applications such as drug delivery, gene delivery, sensors, surfaces, membranes, and chromatography.
pH-sensitive polymer systems combined with nanotechnology could be utilized as an alternative strategy to traditional targeting systems to overcome major problems in current chemotherapy represented by non-specific tissue distribution of the drugs, tumor heterogeneity, and multidrug resistance (MDR) against anticancer drugs.
pH-sensitive polymer systems combined with nanotechnology could be utilized as an alternative strategy to traditional targeting systems to overcome major problems in current chemotherapy represented by non-specific tissue distribution of the drugs, tumor heterogeneity, and multidrug resistance (MDR) against anticancer drugs.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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pH-Responsive polymers
Kocak G, et al.
Polym. Chem., 8, 144-176 (2017)
Girish Kumar Tripathi et al.
Current drug delivery, 8(6), 667-677 (2012-02-09)
Helicobacter pylori reside in the gastric mucus layer and at the mucus-epithelial cell interface wherein access of antimicrobial drug to the infection site is restricted both from the stomach and from the gastric blood supply. The aim of the present
Jing Xie et al.
Macromolecular rapid communications, 38(23), 1499-1499 (2017-10-05)
Since diabetes mellitus has become one of the most serious threats to human health, researchers have been designing new drugs and developing new technologies to control the blood glucose level (BGL) while improving patient compliance. In addition to the traditional
pH-sensitive polymers for drug delivery.
Huh K M, et al.
Macromolecular Research, 20(3), 224-233 (2012)
Cationic Salecan-based hydrogels for release of 5-fluorouracil.
Qi X, et al.
Royal Society of Chemistry Advances, 7, 14337-14347 (2017)
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