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901459

Sigma-Aldrich

Allyl poly(ethylene glycol)-block-poly(lactide-co-glycolide)

PEG average Mn 5000, PLGA average Mn 15000, lactide:glycolide (50:50)

Synonym(s):

Allyl-PEG-b-PLGA, Allyl-PEG-PLGA

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About This Item

Linear Formula:
C3H5O(C2H4O)n[(C2H2O2)x(C3H4O2)y]m
UNSPSC Code:
51171641
NACRES:
NA.23

description

Feed Ratio: 50:50+/-5 (Lactide:Glycolide, by NMR)
Identity: Conforms to structure (by NMR)

form

powder

feed ratio

lactide:glycolide (50:50)
lactide:glycolide±5 (50:50)

mol wt

PEG Mn 4000-6000 g/mol (NMR)
PEG average Mn 5000
PLGA Mn 13500-16500 g/mol (NMR)
PLGA average Mn 15000

color

white

storage temp.

−20°C

Application

Allyl poly(ethylene glycol)-block-poly(lactide-co-glycolide) is an allyl-functionalized, biocompatible, amphiphilic block copolymer. Due to its self-assembling properties, this material can be used in the formation of nanoparticles for drug delivery. Additionally, due to the allyl-functionalization of the PEG block, this material can be used to covalently conjugate biomolecules, API, or targeting ligands rapidly. Potential uses include the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anaesthetic agents.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

>230.9 °F

flash_point_c

> 110.5 °C

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN6798
MKCG2644

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Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties and nanomedical applications as drug delivery system.
Locatelli E, et al.
Journal of Nanoparticle Research, 14, 1316-1316 (2012)
Polymer degradation and drug delivery in PLGA-based drug-polymer applications: A review of experiments and theories.
Xu Y, et al.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 105, 1692-1716 (2017)
Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties and nanomedical applications as drug delivery system
Locatelli E, et al
Journal of Nanoparticle Research, 14, 1316-1316 (2012)
Ilaria Monaco et al.
Journal of medicinal chemistry, 60(10), 4510-4516 (2017-05-05)
Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high

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