900914

Methyltetrazine-NHS ester

≥95%

• Synonym(s): 2,5-Dioxo-1-pyrrolidinyl 4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzeneacetate
• Empirical Formula (Hill Notation): C₁₅H₁₃N₅O₄
• CAS Number: 1644644-96-1
• Molecular Weight: 327.29
• MDL number: MFCD28334557
• UNSPSC Code: 12352108
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥95%
• form: powder or crystals
• reaction suitability: reaction type: click chemistry; reagent type: cross-linking reagent
• functional group: NHS ester
• storage temp.: −20°C
• SMILES string: O=C(ON1C(CCC1=O)=O)CC(C=C2)=CC=C2C3=NN=C(C)N=N3

Description

Application

Methyltetrazine-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and a methyltetrazine, which is reactive to trans-cyclooctenes. The NHS ester reacts with primary amines (e.g. side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. The short spacer arm adds minimal mass to modified molecules (230.2 daltons). It is generally used in click chemistry applications in bioconjugate chemistry.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable