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900912

Sigma-Aldrich

Biotin picolyl azide

Synonym(s):

Biotin-functionalized Picolyl Azide

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50 MG
$504.00

About This Item

Empirical Formula (Hill Notation):
C27H42N8O7S
Molecular Weight:
622.74
UNSPSC Code:
12352125
NACRES:
NA.22

$504.00


Available to ship onApril 29, 2025Details


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form

powder or crystals

Quality Level

reaction suitability

reaction type: click chemistry

storage temp.

−20°C

Application

Biotin picolyl azide is a linker with an azide group for attachment to alkynes, a biotin for capture by streptavidin, and a picolyl group for faster azide reactivity. The picolyl azide chelates Cu(I) to enhance the reactivity of the azide-alkyne cycloaddition.[1][2] This is an advantage especially when working with low concentrations of alkynes and can also enable reduction of the copper concentration.

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Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions.
Yang B, et al.
Nature Communications, 8(1), 2240-2240 (2017)
A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins.
Gaebler A, et al.
Journal of Lipid Research, 57(10), 1934-1947 (2016)
Lydia Boike et al.
Cell chemical biology, 28(1), 4-13 (2020-09-24)
MYC is a major oncogenic transcriptional driver of most human cancers that has remained intractable to direct targeting because much of MYC is intrinsically disordered. Here, we have performed a cysteine-reactive covalent ligand screen to identify compounds that could disrupt

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