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861804

Sigma-Aldrich

8-(Diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride

97%

Synonym(s):

TMB 8 hydrochloride, TMB-8 · HCl

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About This Item

Linear Formula:
(CH3O)3C6H2CO2(CH2)8N(C2H5)2 · HCl
CAS Number:
53464-72-5
Molecular Weight:
431.99
Beilstein/REAXYS Number:
5466611
EC Number:
258-574-5
MDL number:
MFCD00012502
UNSPSC Code:
12352100
PubChem Substance ID:
329769446

assay

97%

form

powder

mp

94-97 °C (lit.)

SMILES string

Cl[H].CCN(CC)CCCCCCCCOC(=O)c1cc(OC)c(OC)c(OC)c1

InChI

1S/C22H37NO5.ClH/c1-6-23(7-2)14-12-10-8-9-11-13-15-28-22(24)18-16-19(25-3)21(27-5)20(17-18)26-4;/h16-17H,6-15H2,1-5H3;1H

InChI key

KFJZVXKPPQIYCG-UHFFFAOYSA-N

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Application

  • Pharmacologically active inhibitor of hepatitis C virus life cycle

replaced by

Product No.
Description
Pricing

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Maria A Mariggiò et al.
Peptides, 29(9), 1486-1497 (2008-06-25)
The two major isoforms (180 kDa and 140 kDa) of the neural cell adhesion molecule (N-CAM) are crucially involved in neurogenesis and brain repair via activation of the mitogen-activated protein kinase (MAPK) cascade. Modification by glycosylation, and homophilic and heterophilic
P Fang et al.
Acta physiologica (Oxford, England), 199(1), 53-61 (2010-01-20)
The aim of this study was to determine the effects of motilin on [Ca(2+)](i) regulation and its underlying molecular mechanism in cultured antral smooth muscle cells (ASMCs). Antral cells were isolated and cultured from neonatal rats, and then the [Ca(2+)](i)
Agata Adamczyk et al.
Folia neuropathologica, 43(3), 139-142 (2005-10-26)
Our previous studies indicated that Alzheimer's disease (AD) related amyloid beta peptide (Abeta) significantly altered muscarinic cholinergic receptor (mChR) signaling on the level of G protein regulated phospholipase C (PLC) leading to the lower formation of inositol-1,4,5-triphosphate (IP3) and diacylglycerol
Jafar Vatanparast et al.
European journal of pharmacology, 571(2-3), 81-87 (2007-06-30)
We have previously reported that paraoxon, an organophosphate compound, at submicromolar concentrations effectively suppresses Ca2+ action potentials and modulates the activity of snail neurons. This effect was unrelated to acetylcholinesterase inhibition but was found to involve the direct or indirect
Fabián Bernal et al.
Journal of neuroscience research, 87(5), 1240-1249 (2008-11-14)
Human cerebral calcification has been related to deregulation of intracellular calcium homeostasis. In rat basal ganglia, nimodipine and TMB-8, two commonly used calcium antagonists, worsen the chronic AMPA-induced lesion, whereas only nimodipine potentiates calcification. To investigate whether similar effects are
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