808962
Gold nanoparticles
100 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O
Synonym(s):
Biotin Gold
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About This Item
UNSPSC Code:
12141717
NACRES:
NA.23
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material
PEG 5000
Quality Level
form
dispersion in H2O
nanoparticles
composition
, 1.92E11 particles/mL
packaging
pkg of 0.5 mL
storage condition
do not freeze
concentration
3.89E-02 mg/mL W
OD
50
surface area
3.08 m2/g
diameter
100 nm
pH
5-7
density
1.00 g/cm3
λmax
572 nm
functional group
biotin
storage temp.
2-8°C
InChI
1S/Au
InChI key
PCHJSUWPFVWCPO-UHFFFAOYSA-N
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General description
Concentrations is indicated at an optical density of 1 (OD=1, i.e. absorbance at peak SPR wavelength with a 1cm pathlength)
Gold nanoparticles PEG 5000 biotin terminated.The preparation of biotinylated gold nanoparticles involves two surface modification steps. First, the carboxyl-terminated alkanethiol is attached to the surface of gold nanoparticles via chemisorption in the presence of a stabilizing agent. This step is followed by the reaction of the carboxyl groups with (+)-biotinyl-3,6,9,-trioxaundecanediamine and 2-(2-aminoethoxy)ethanol.[1]
Application
Biotin functionalized gold nanoparticles are suitable for binding of streptavidin labelled conjugates. The gold nanoparticle label allows for straightforward detection of streptavidin by measuring the increase in absorbance of the sample upon binding. The absorption maximum is gold nanoparticle size dependent and ranges from 515-520nm for a 5nm particle to 572nm for a 100nm particle.
Gold nanoparticles 100 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O can be used as a theranostic agent for potential usage in cancer therapy and treatment of COVID-19.[2][3] It can also be used in the detection of pathogens for biosensing applications.[4][5] AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique.[6][7]
Legal Information
Product of CytoDiagnostics, Inc.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Controlled and reversible aggregation of biotinylated gold nanoparticles with streptavidin.
Aslan K
The Journal of Physical Chemistry B, 108 (40), 15631-15639 (2004)
Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy
Heo DN, et al.
Biomaterials, 33(3), 856-866 (2012)
Colorimetric biosensing of pathogenss using gold nanoparticles
Verma MS, et al.
Biotechnology Advances, 33(6), 666-680 (2015)
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 33(6), 666-680 (2020)
Localized surface plasmon resonance (LSPR) of polyelectrolyte-functionalized gold-nanoparticles for bio-sensing
Li X, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 332(2-3), 172-179 (2009)
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