790257

Poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) based poly(ether ester urethane)

average M_n 6,000-12,000

• Synonym(s): Poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) based poly(ether ester urethane)
• Linear Formula: [C₂H₂N₂O₂R[(C₃H₄O₂)_x(C₂H₂O₂)_y]_m[C₂H₄O]lO[(C₃H₄O₂)_x(C₂H₂O₂)_y]_m]_n
• UNSPSC Code: 12352100

Properties

• form: paste
• feed ratio: (Prepolymer (PLGA-PEG-PLGA): Diisocyanate :: 1:0.8); PEG:DL-lactide:glycolide 19:65:16; lactide:glycolide 1:0.8
• mol wt: PEG average M_n 400; average M_n 6,000-12,000
• degradation timeframe: <4 months
• viscosity: 8.79 Pa.s(100 °C) (at Angular Frequency (1/s) 5.46 Anton-Parr Rhometer); 466 Pa.s(50 °C) (at Angular Frequency (1/s) 1.33, Anton-Parr Rhometer)
• transition temp: T_g <0 °C
• PDI: <2.0
• storage temp.: 2-8°C
• SMILES string: CC(N[R]NC(OC(C)C(OCC(OCCOC(C(C)OC(COC)=O)=O)=O)=O)=O)=O.CC(N[R]NC(OCCCOC)=O)=O

Description

Application

• This poly(ether ester urethane) based on PLGA-PEG-PLGA triblock copolymers linked with a diisocyanate is a biodegradable; resorbable gel former for use in drug delivery systems.
• This polymer doesn′t rely on temperature or pH to induce gelation and therefore form more consistent and faster-setting drug delivery depots.
• Through combination of various gel formers and/or diluents; drug release profiles may be modulated to exhibit fast burst release through extended (up to 1 month) zero-order release profile.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable