790249

Poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) based poly(ether ester urethane)

average M_n (6,000-15,000)

• Synonym(s): PEEU, PLGA-PEG-PLGA urethane, VISCOPRENE^® 9, poly(ester ether urethane)
• Linear Formula: [C₂H₂N₂O₂R[(C₃H₄O₂)_x(C₂H₂O₂)_y]_m[C₂H₄O]lO[(C₃H₄O₂)_x(C₂H₂O₂)_y]_m]_n
• UNSPSC Code: 12352100
• PubChem Substance ID: 329768204
• NACRES: NA.23

Properties

• form: amorphous solid
• feed ratio: 13:(70:17) (PEG:(D,L-lactide:glycolide)); lactide:glycolide 80:20
• mol wt: PEG average M_n 400; average M_n (6,000-15,000)
• degradation timeframe: <4 months
• transition temp: T_g <0 °C
• PDI: <2.0
• storage temp.: 2-8°C
• SMILES string: CC(N[R]NC(OC(C)C(OCC(OCCOC(C(C)OC(COC)=O)=O)=O)=O)=O)=O.CC(N[R]NC(OCCCOC)=O)=O

Description

Application

This poly(ether ester urethane) based on PLGA-PEG-PLGA triblock copolymers linked with a diisocyanate is a biodegradable, resorbable gel former for use in drug delivery systems. This polymer doesn′t rely on temperature or pH to induce gelation, and therefore forms more consistent and faster-setting drug delivery depots. Through combination of various gel formers and/or diluents, drug release profiles may be modulated to exhibit fast burst release through extended (up to 1 month) zero-order release profile. Mass loss of the resultant drug delivery depots is complete within 4 months.

Legal Information

Product of Poly-Med, Inc. VISCOPRENE^® is a registered trademark of Poly-Med, Inc.

Viscoprene is a registered trademark of Poly-Med, Inc.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable