This poly(L-lactide) is a well-defined, biodegradable polymer which is functionalized with an alcohol on one end and an acrylate on the other. Acrylates are commonly used in polymerizations or in ligatation to thiols with thiol-ene click chemistry. Polylactide is commonly used in several applications including drug delivery, compatibilizer, emulsifier, thermoplastic elastomer or impact-resistant plastic.
Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.
Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.
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