765392
Gold nanoparticles
40 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
Synonym(s):
Gold nanoparticles NH2 functionalized, Au NP NH2, Gold Colloid
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About This Item
UNSPSC Code:
12162002
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material
PEG 5000
Quality Level
form
dispersion in H2O
nanoparticles
packaging
poly bottle of 1 mL
OD
50
diameter
40 nm
pH
6.0-8.0 (25 °C)
solubility
water: miscible
density
1.00 g/cm3
functional group
amine
storage temp.
2-8°C
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General description
Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. AuNPs, as aggregates, is shown to be highly sensitive colloidal biosensors. Poly (ethylene) glycol (PEG) surface coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which has Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.[1][2][3][4]
Application
Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:
- Since they adhere to cell membranes, AuNPs are used in cellular and intracellular targeting in targeted drug delivery applications and can also be used in biodistribution studies
- AuNPs may also be used in photothermal therapy and radiotherapy.
- AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.
- They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.[4][5]
Features and Benefits
- A negatively charged siRNA-PEG complex attached to positively charged GNPs is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.[4] [5]
- The PEG coating decreases the cytotoxicity and increases effciciency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.[2]
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.
Sarah D Brown et al.
Journal of the American Chemical Society, 132(13), 4678-4684 (2010-03-17)
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of
Scott H Brewer et al.
Langmuir : the ACS journal of surfaces and colloids, 21(20), 9303-9307 (2005-09-21)
The interaction of bovine serum albumin (BSA) with gold colloids and surfaces was studied using zeta-potential and quartz crystal microbalance (QCM) measurements, respectively, to determine the surface charge and coverage. The combination of these two measurements suggests that BSA binding
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
Xiao-Dong Zhang et al.
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)
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The recent emergence of a number of highly functional nanomaterials has enabled new approaches to the understanding, diagnosis, and treatment of cancer.
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