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760927

Sigma-Aldrich

Poly(ethylene glycol), 16 acetylene dendron, generation 3

average Mn 8,000

Synonym(s):

Bis-MPA poly(ethylene glycol), Bis[2,2-bis(hydroxymethyl)propanoic acid] PEG, Dendron functionalized PEG acetylene, generation 3, PEG-6000, PFD-G3-PEG6k-Acetylene

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About This Item

UNSPSC Code:
12162002

description

acetylene surface groups

form

solid

mol wt

PEG average Mn 6,000 (n~130, esterified with 16 acetylene groups)
Mn 7500-9500 (by NMR)
average Mn 8,000

feature

generation 3

no. Surface Groups

16

mp

43-47 °C

functional group

alkyne

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General description

Dendrimers and dendrons are symmetrically branched polymer structures that possess a well-defined spatial distribution of functional groups. Dendrimers are chemically modified by attaching poly ethylene glycol (PEG) molecule to increase its solubility and prolong circulation half-life.“Clickable groups”, such as primary acetylenes, are introduced to the mono dispersed dendritic structures, using “click” chemistry. These acetylene groups, attached to Bis-MPA based dendrons, allow it to form the conjugates with bioactive moieties such as carbohydrate, fluorescent dyes, disaccharides etc.

Application

The proposed uses are
  • as an efficient drug delivery system.
  • In vitro toxicological studies
  • In vivo via radionuclide labeling and optical imaging
  • Biosensors
  • Dip pen nanolithography

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

No data available

flash_point_c

No data available

Certificates of Analysis (COA)

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Applications of Orthogonal, ?click? Chemistries in the synthesis of functional soft materials
Chemical Reviews, 109 (11), 5620-5686 null
Degradable Poly (ethylene glycol) hydrogels for 2 D and 3D cell culture
Andrea M Kasko
Material Matters, 6 (3), 67-75 null
Biocompatible Dendritic Building Blocks for Advanced Biomedical Reasearch
Michael Malkoch and Andreas M Nystrom
Material Matters, 7(3), 47-49 null
Huiyuan Li et al.
Molecules (Basel, Switzerland), 18(8), 9797-9817 (2013-08-21)
Click chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly used to construct diverse chemotypes

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