760870
Poly(ethylene glycol), 32 hydroxyl dendron, generation 4
average Mn 9,500
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About This Item
UNSPSC Code:
12162002
NACRES:
NA.23
description
hydroxyl surface groups
form
solid
mol wt
PEG average Mn 6,000 (n~130; esterified with 16 OH groups)
average Mn 9,500
feature
generation 4
no. Surface Groups
32
transition temp
Tm 42-48 °C
functional group
hydroxyl
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General description
Dendrimers with Poly(ethylene) glycol (PEG) core are widely used in drug delivery systems. These dendrimers are end functionalized with hydroxyl groups which increas its biocompatibility. PEG is used as the core since it is non-toxic, non-immunogenic with favorable pharmacokinetic and tissue distribution. They are also soluble in aqueous and many organic solvents.†††
Features and Benefits
Well-defined structure, high intrinsic drug loading capability, flexibility for tailored functionalization.[1]
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Pharmaceutical and biomedical potential of PEGylated dendrimers.
Gajbhiye, V., Vijayaraj Kumar, P., Kumar Tekade, R., & Jain, N. K.
Current Pharmaceutical Design, 13(4), 415-429 (2007)
Chiara Clementi et al.
Molecular pharmaceutics, 8(4), 1063-1072 (2011-05-26)
Poly(ethylene glycol) (PEG) is the most popular polymer for protein conjugation, but its potential as carrier of low molecular weight drugs has been limited by the intrinsic low loading, owing to its chemical structure. In fact, only the two end
Marco D Giles et al.
Journal of the American Chemical Society, 130(44), 14430-14431 (2008-10-14)
At neutral pH, dendronized deep-cavity cavitands were shown to form supramolecular nanocapsules via assembly around a range of guest molecules.
Omayra L Padilla De Jesús et al.
Bioconjugate chemistry, 13(3), 453-461 (2002-05-16)
High molecular weight polymers (> 20 000 Da) have been widely used as soluble drug carriers to improve drug targeting and therapeutic efficacy. Dendritic polymers are exceptional candidates for the preparation of near monodisperse drug carriers due to their well-defined
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