The validation of an analytical method for the measurement of the unnatural amino acid alpha-fluoro-beta-alanine (AFBA), the main metabolite of the antineoplastic drug 5-fluorouracil (5FU), in urine for the biological monitoring of the exposure of hospital workers to the drug
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(11-12), 1040-1046 (2009-03-17)
A sensitive and selective quantitative method to determine alpha-fluoro-beta-alanine (FBAL), 5-fluorouracil (5-FU), and capecitabine (Cape) from a single human plasma aliquot (50 microL) has been developed and validated. First, 5-FU and Cape were extracted by liquid-liquid extraction (LLE) using a
International journal of clinical oncology, 10(6), 441-443 (2005-12-22)
Cardiotoxicity is a rare complication occurring during 5-fluorouracil (5-FU) treatment for malignancies. We herein report the case of a 70-year-old man with 5-FU-induced cardiotoxicity, in whom a high serum level of alpha-fluoro-beta-alanine (FBAL) was observed. The patient, who had unresectable
Magnetic resonance in medicine, 50(2), 303-308 (2003-07-24)
Fluorine MR spectroscopy ((19)F MRS) is an indispensable tool for assessing the pharmacokinetics of fluorinated drugs. Since the metabolism of 5-fluorouracil (5FU), a frequently used cytotoxic drug, is expected to be different in normal liver and in tumor tissue, spatial
American journal of ophthalmology, 142(1), 194-196 (2006-07-04)
The aim of this study is to determine if systemic absorption is present after 5-fluorouracil (5FU) is used in the vitrectomy infusion. A two-case clinical study. A catabolite of 5FU, alpha-fluoro-beta-alanine (FBAL), was measured in urine samples of two patients
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