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685178

Sigma-Aldrich

N,N′-Dicyclohexylcarbodiimide, ChemDose™ tablets

Loading: 0.15mmol per tablet

Synonym(s):

ChemDose™, N,N′-Dicyclohexylcarbodiimide impregnated tablets, DCC impregnated tablets

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About This Item

Linear Formula:
C6H11N=C=NC6H11
CAS Number:
538-75-0
Molecular Weight:
206.33
MDL number:
MFCD00011639
UNSPSC Code:
12352200
PubChem Substance ID:
24885835

form

tablet

matrix

Magnesium aluminometasilicate base material

InChI

1S/C20H18N2O2/c1-3-22(4-2)13-9-10-16-18(11-13)24-19-12-17(23)14-7-5-6-8-15(14)20(19)21-16/h5-12H,3-4H2,1-2H3

InChI key

VOFUROIFQGPCGE-UHFFFAOYSA-N

Legal Information

ChemDose is a trademark of Reaxa Ltd.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
06703DH

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Heghine Torgomyan et al.
FEMS microbiology letters, 329(2), 131-137 (2012-02-01)
Exposure to electromagnetic irradiation (EMI) of 51.8 and 53.0 GHz and low intensity (flux capacity of 0.06 mW cm(-2) ) for 1 h markedly decreased the energy-dependent H(+) and K(+) transport across membranes of Enterococcus hirae ATCC 9790. After EMI, there was also a
Alain Dautant et al.
The Journal of biological chemistry, 285(38), 29502-29510 (2010-07-09)
The F(1)c(10) subcomplex of the yeast F(1)F(0)-ATP synthase includes the membrane rotor part c(10)-ring linked to a catalytic head, (αβ)(3), by a central stalk, γδε. The Saccharomyces cerevisiae yF(1)c(10)·ADP subcomplex was crystallized in the presence of Mg·ADP, dicyclohexylcarbodiimide (DCCD), and
Ryutaro Tokutsu et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(24), 10016-10021 (2013-05-30)
Plants and green algae have a low pH-inducible mechanism in photosystem II (PSII) that dissipates excess light energy, measured as the nonphotochemical quenching of chlorophyll fluorescence (qE). Recently, nonphotochemical quenching 4 (npq4), a mutant strain of the green alga Chlamydomonas
Denys Pogoryelov et al.
Nature chemical biology, 6(12), 891-899 (2010-10-26)
The microscopic mechanism of coupled c-ring rotation and ion translocation in F(1)F(o)-ATP synthases is unknown. Here we present conclusive evidence supporting the notion that the ability of c-rings to rotate within the F(o) complex derives from the interplay between the
Masashi Toei et al.
The Journal of biological chemistry, 288(36), 25717-25726 (2013-07-31)
N,N-Dicyclohexylcarbodiimide (DCCD) is a classical inhibitor of the F0F1-ATP synthase (F0F1), which covalently binds to the highly conserved carboxylic acid of the proteolipid subunit (c subunit) in F0. Although it is well known that DCCD modification of the c subunit
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Questions

1–7 of 7 Questions  

  1. Do the ChemDose® tablets disintegrate during the course of the reaction?

    1 answer

    1. They are normally recovered intact, however, they may disintegrate somewhat in aqueous reactions. Any disintegrated tablets can be removed from the reaction via filtration.

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  2. Can I use ChemDose® tablets in any solvent?

    1 answer

    1. Yes, including aqueous solvents.

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  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  4. Can I use ChemDose® tablets in a microwave or pressure vessel?

    1 answer

    1. Absolutely. Please see the Technical Information for Download section (below) for additional examples of cross-coupling reactions involving the use of microwaves.

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  5. How should I store ChemDose® tablets?

    1 answer

    1. As with most catalysts and ligands, as a general precaution it is best to store them in a refrigerator and/or under an inert atmosphere to maintain activity. Some catalysts, such as Pd(dppf)Cl2·CH2Cl2, are more robust and can be handled in air without issue. Please refer to the ChemDose® label for specific handling of a given catalyst, ligand, or reagent.

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  6. What is the pH stability of the ChemDose® tablets?

    1 answer

    1. The ChemDose® tablets are mildly basic and will dissolve in the presence of mineral acids.

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  7. How should I dispose of spent ChemDose® tablets?

    1 answer

    1. They should be treated as solid waste, contaminated with reaction species. The matrix is non-toxic and environmentally benign.

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