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684929

Sigma-Aldrich

Palladium(II) acetate, ChemDose™ tablets

Loading: 2μmol per tablet

Synonym(s):

ChemDose™, Palladium(II) acetate tablets, Palladium(II) acetate impregnated tablets, Pd(OAc)2 impregnated tablets

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About This Item

Linear Formula:
Pd(OCOCH3)2
CAS Number:
3375-31-3
Molecular Weight:
224.51
MDL number:
MFCD00012453
UNSPSC Code:
12352300
PubChem Substance ID:
329760933

form

tablet

reaction suitability

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst

matrix

Magnesium aluminometasilicate base material

SMILES string

CC(=O)O[Pd]OC(C)=O

InChI

1S/2C2H4O2.Pd/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2

Inchi Key

YJVFFLUZDVXJQI-UHFFFAOYSA-L

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Application

ChemDose: Convenient Dosing of Catalysts and Reagents

Legal Information

ChemDose is a trademark of Reaxa Ltd.

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
06603DH

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Jinyue Ding et al.
Nature communications, 5, 5474-5474 (2014-11-19)
Non-aromatic nitrogen- and oxygen-containing heterocycles such as piperidines and pyrans are prevalent components of natural products and pharmaceutical drugs. Although it has been a workhorse as a synthetic method for assembling unsaturated sp(2)-hybridized substrates, transition metal-catalysed cross-coupling chemistry is traditionally

Questions

1–8 of 8 Questions  

  1. Can I use ChemDose® tablets in a microwave or pressure vessel?

    1 answer

    1. Absolutely. Please see the Technical Information for Download section (below) for additional examples of cross-coupling reactions involving the use of microwaves.

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  2. How should I store ChemDose® tablets?

    1 answer

    1. As with most catalysts and ligands, as a general precaution it is best to store them in a refrigerator and/or under an inert atmosphere to maintain activity. Some catalysts, such as Pd(dppf)Cl2·CH2Cl2, are more robust and can be handled in air without issue. Please refer to the ChemDose® label for specific handling of a given catalyst, ligand, or reagent.

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  3. What is the pH stability of the ChemDose® tablets?

    1 answer

    1. The ChemDose® tablets are mildly basic and will dissolve in the presence of mineral acids.

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  4. Can I use ChemDose® tablets in any solvent?

    1 answer

    1. Yes, including aqueous solvents.

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  5. What is the difference between Product 520764, Palladium (II) acetate, and the palladium acetate in the form of a ChemDose® tablet?

    1 answer

    1. The ChemDose® products offer a streamlined way to catalyze reactions. The catalyst is dispersed in an inert tablet matrix in specific millimolar and micromolar quantities. The tablets can decrease time spent on weighing/adding the catalyst to the reaction mixture. The tablets effectively give the same reaction yields with a controlled release of the catalyst. They are also extremely easy to remove after the reaction is complete. The inert tablet usually stays intact throughout the reaction. Product 684929 is the ChemDose® tablet that contains 2.0 μmol of palladium (II) acetate, while product#: 685593 is the 10μmol version. More information on these products can be found at the link below.

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  6. How should I dispose of spent ChemDose® tablets?

    1 answer

    1. They should be treated as solid waste, contaminated with reaction species. The matrix is non-toxic and environmentally benign.

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  7. Do the ChemDose® tablets disintegrate during the course of the reaction?

    1 answer

    1. They are normally recovered intact, however, they may disintegrate somewhat in aqueous reactions. Any disintegrated tablets can be removed from the reaction via filtration.

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  8. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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