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Sigma-Aldrich

2,4-Difluoropyrimidine

97%

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About This Item

Empirical Formula (Hill Notation):
C4H2F2N2
CAS Number:
2802-61-1
Molecular Weight:
116.07
MDL number:
MFCD04972830
UNSPSC Code:
12352100
PubChem Substance ID:
24884500
NACRES:
NA.22

assay

97%

refractive index

n20/D 1.432

bp

118-120 °C

density

1.359 g/mL at 25 °C

SMILES string

Fc1ccnc(F)n1

InChI

1S/C4H2F2N2/c5-3-1-2-7-4(6)8-3/h1-2H

InChI key

JZSYSXZDIQUOGP-UHFFFAOYSA-N

Application

2,4-Difluoropyrimidine can be used as a starting material to synthesize:
  • 3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH1) inhibitors.
  • N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

106.0 °F - closed cup

flash_point_c

41.1 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Optimization of 3-pyrimidin-4-yl-oxazolidin-2-ones as orally bioavailable and brain penetrant mutant IDH1 inhibitors
Zhao Q, et al.
ACS Medicinal Chemistry Letters, 9(7), 746-751 (2018)
Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity
Zhu A, et al.
Journal of Medicinal Chemistry, 53(24), 8556-8568 (2010)

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