567280
4-(3-Hydroxypropyl)morpholine
95%
Synonym(s):
3-(4-Morpholinyl)-1-propanol, 3-Morpholinopropanol
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About This Item
Empirical Formula (Hill Notation):
C7H15NO2
CAS Number:
Molecular Weight:
145.20
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
Recommended Products
assay
95%
impurities
may contain ~5% morpholine
refractive index
n20/D 1.4770 (lit.)
bp
240-241 °C (lit.)
density
1.049 g/mL at 25 °C (lit.)
SMILES string
OCCCN1CCOCC1
InChI
1S/C7H15NO2/c9-5-1-2-8-3-6-10-7-4-8/h9H,1-7H2
InChI key
VZKSLWJLGAGPIU-UHFFFAOYSA-N
Application
4-(3-Hydroxypropyl)morpholine may be used in the synthesis of macrocyclic urea compounds, which can act as potent Chk1 inhibitors.[1]
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Repr. 2 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk_germany
WGK 3
flash_point_f
185.0 °F - closed cup
flash_point_c
85 °C - closed cup
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David Johansson et al.
BMC cancer, 9, 67-67 (2009-02-28)
The prerequisite for the potential use of the bacterial toxin verotoxin-1 in the treatment of breast cancer was investigated by first determining the expression of its receptor Gb3 (CD77) in clinical breast cancer tissue specimens. We then examined the cytotoxicity
"Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors"
Li J, et al.
Bioorganic & Medicinal Chemistry Letters, 17(23), 6499-6504 (2007)
Y Jiang et al.
Journal of biological regulators and homeostatic agents, 34(6), 2029-2036 (2020-12-12)
Dysregulation of the adipo-osteogenic differentiation balance of mesenchymal stem cells (MSCs), which are common progenitor cells of adipocytes and osteoblasts, has been associated with many pathophysiologic diseases, such as obesity, osteopenia, and several neurodegenerative disorders. Growing evidence suggests that lipid
Weihong Xu et al.
Biochemical and biophysical research communications, 463(4), 545-550 (2015-06-01)
In the current study, we investigated the potential activity of AR-42, a novel histone deacetylase (HDAC) inhibitor, against colon cancer cells. Our in vitro results showed that AR-42 induced ceramide production, exerted potent anti-proliferative and pro-apoptotic activities in established (SW-620 and
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